Welsh Breanne L, Sikder Prabaha
Department of Mechanical Engineering, Cleveland State University, Cleveland, Ohio, USA.
J Biomed Mater Res B Appl Biomater. 2025 Jan;113(1):e35520. doi: 10.1002/jbm.b.35520.
Osteoarthritis (OA) is a prevalent joint disorder that is characterized by the degeneration of articular cartilage in synovial joints. Most of the current treatment options for this disorder tend to focus on symptom management rather than addressing the underlying progression of the disease. Cartilage tissue engineering has emerged as a promising approach to address the limitations of current OA treatments, aiming to regenerate cartilage and restore the natural function of affected joints. Like any other tissue engineering field, cartilage tissue engineering uses different fabrication techniques and biomaterials to develop the constructs. Numerous studies over the last few years have demonstrated the preclinical efficacy of tissue-engineered constructs in promoting cartilage regeneration and highlight the potential of tissue-engineered constructs as a viable therapeutic approach for OA. This paper aims to provide a focused review of advancements in tissue-engineered constructs over the past decade. Specifically, we highlight the constructs based on natural, synthetic, and composite biomaterials and the varying conventional and advanced fabrication techniques. We also highlight the challenges in state-of-the-art cartilage tissue engineering that must be overcome in the upcoming years to fully replicate the complex anatomy of the native cartilage. We believe that continued collaborative research efforts among researchers from various facets of engineering and clinicians are required to advance the field of cartilage tissue engineering and become a viable OA therapy.
骨关节炎（OA）是一种常见的关节疾病，其特征是滑膜关节的关节软骨退变。目前针对这种疾病的大多数治疗选择往往侧重于症状管理，而非解决疾病的潜在进展问题。软骨组织工程已成为一种有前景的方法，以解决当前骨关节炎治疗的局限性，旨在再生软骨并恢复受影响关节的自然功能。与任何其他组织工程领域一样，软骨组织工程使用不同的制造技术和生物材料来构建结构体。过去几年的大量研究证明了组织工程结构体在促进软骨再生方面的临床前疗效，并突出了组织工程结构体作为骨关节炎可行治疗方法的潜力。本文旨在重点回顾过去十年组织工程结构体方面的进展。具体而言，我们将重点介绍基于天然、合成和复合生物材料的结构体以及不同的传统和先进制造技术。我们还将强调当前软骨组织工程面临的挑战，这些挑战在未来几年必须克服，才能完全复制天然软骨的复杂解剖结构。我们认为，工程领域各方面的研究人员与临床医生之间持续的合作研究努力对于推动软骨组织工程领域发展并成为可行的骨关节炎治疗方法至关重要。
