Cinti S, Sbarbati A, Balercia G, Cigolini M
Acta Anat (Basel). 1985;121(2):94-8. doi: 10.1159/000145950.
The microcysts found in two adenohypophyses removed from patients with nonsecreting adenomas of this gland have been studied. In one case the cysts were completely surrounded by neoplastic tissue, whereas in the second they were located within the normal parenchyma. The cysts were surrounded by a basement membrane, and appeared to contain a finely granular weakly electron-dense substance. Their walls were lined by mostly cubic cells with microvilli, joined by junctional complexes. Intracytoplasmic microlumina could be seen in some of these cells. Cells showing cilia with a 9 + 2 fibrillar pattern and cells with mucosecretory differentiation were also present. Furthermore endocrine cells were also found in the cyst-lining epithelium. The ultrastructural aspects of the cyst cells lead to reject the hypothesis that these are derived from folliculostellate cells. Besides, intermediate aspects between cyst cells and tumor cells were never visible. Therefore it seems likely that a relationship between adenoma and cyst cells does not exist and that cyst cells originate from remnants of Rathke's pouch with a ciliate or mucosecretory differentiation. The presence of endocrine cells in the cyst-lining epithelium deserves further study, for it seems to indicate that an endocrine differentiation may occur in the adult, too. To our knowledge this is the first ultrastructural study of these structures in adult human pituitary gland.
对从患有该腺体无分泌性腺瘤的患者身上切除的两个腺垂体中发现的微囊肿进行了研究。在一个病例中，囊肿完全被肿瘤组织包围，而在另一个病例中，它们位于正常实质内。囊肿被基底膜包围，似乎含有一种细颗粒状、电子密度低的物质。囊肿壁内衬大多为立方体细胞，有微绒毛，通过连接复合体相连。在其中一些细胞中可见胞质微腔。还存在显示9 + 2纤维模式纤毛的细胞和具有黏液分泌分化的细胞。此外，在囊肿内衬上皮中也发现了内分泌细胞。囊肿细胞的超微结构特征使人们否定了这些细胞来源于滤泡星形细胞的假说。此外，囊肿细胞和肿瘤细胞之间从未可见中间形态。因此，腺瘤与囊肿细胞之间似乎不存在关系，囊肿细胞起源于拉特克囊的残余，具有纤毛或黏液分泌分化。囊肿内衬上皮中内分泌细胞的存在值得进一步研究，因为这似乎表明在成年人中也可能发生内分泌分化。据我们所知，这是对成年人类垂体中这些结构的首次超微结构研究。
