氯丙嗪可增强锂诱导的尿崩症大鼠对抗利尿激素降低的反应。

Chlorpromazine increases the lowered response to antidiuretic hormone in rats with lithium-induced diabetes insipidus.

作者信息

Kristensen A R, Hammer M, Christensen S

出版信息

Acta Pharmacol Toxicol (Copenh). 1985 Jan;56(1):63-8. doi: 10.1111/j.1600-0773.1985.tb01254.x.

DOI:10.1111/j.1600-0773.1985.tb01254.x

Abstract

The interaction between chlorpromazine (CPZ) and lithium on renal concentrating ability was studied in rats fed a Li-containing diet for 8 weeks (plasma-Li 0.6-0.7 mmol/l). CPZ (15 mg/kg daily orally) reduced the polydipsia and increased the ability to concentrate the urine upon water deprivation in rats treated with lithium. CPZ also reduced systolic blood pressure, but had no effect on the glomerular filtration rate or plasma levels of arginine vasopressin (AVP) in hydrated rats treated with lithium. However, CPZ prevented the rise in plasma AVP levels observed in lithium-polyuric rats in response to dehydration. During anaesthesia CPZ partially restored the impaired anti-diuretic response to exogenous AVP in rats treated with lithium. CPZ had no influence on plasma-Li levels in rats treated with lithium. It is suggested that CPZ by unknown mechanisms interferes with the effects of lithium on the water permeability response to AVP.

摘要

在喂食含锂饮食8周（血浆锂浓度为0.6 - 0.7 mmol/l）的大鼠中，研究了氯丙嗪（CPZ）与锂对肾脏浓缩能力的相互作用。CPZ（每日口服15 mg/kg）可减少锂处理大鼠的多饮，并增强其禁水时浓缩尿液的能力。CPZ还可降低收缩压，但对锂处理的水合大鼠的肾小球滤过率或精氨酸加压素（AVP）血浆水平无影响。然而，CPZ可阻止锂致多尿大鼠脱水后血浆AVP水平的升高。在麻醉期间，CPZ可部分恢复锂处理大鼠对外源性AVP受损的抗利尿反应。CPZ对锂处理大鼠的血浆锂水平无影响。提示CPZ通过未知机制干扰锂对AVP水通透性反应的影响。