一名年轻免疫功能正常男性因播散性单纯疱疹病毒1型相关噬血细胞性淋巴组织细胞增生症导致的严重急性肝损伤
Severe Acute Liver Injury From Hemophagocytic Lymphohistiocytosis Related to Disseminated Herpes Simplex Virus Type 1 in a Young Immunocompetent Man.
作者信息
Seog Woo Jin, Steinberg Jonathan, Ghafary Ismail, Clores Michael, Aroniadis Olga
机构信息
Stony Brook Medicine, Department of Medicine, Stony Brook University Hospital, Stony Brook, NY.
Stony Brook Medicine, Department of Medicine, Division of Gastroenterology and Hepatology, Stony Brook University Hospital, Stony Brook, NY.
出版信息
ACG Case Rep J. 2025 Jan 4;12(1):e01581. doi: 10.14309/crj.0000000000001581. eCollection 2025 Jan.
Although herpes simplex virus, Epstein-Barr virus, and hemophagocytic lymphohistiocytosis are known causes of severe acute liver injury with or without liver failure, these diseases occur almost exclusively in immunocompromised and elderly patients. We report a case of an immunocompetent young man with no medical history who presented with a subacute cough and persistent fevers in the setting of a penile chancre. He was found to have severely elevated liver chemistries and was subsequently diagnosed with hemophagocytic lymphohistiocytosis because of disseminated herpes simplex virus type 1 and Epstein-Barr virus coinfection. He was treated with intravenous dexamethasone and acyclovir and made a complete recovery.
虽然单纯疱疹病毒、爱泼斯坦-巴尔病毒和噬血细胞性淋巴组织细胞增生症是已知的导致严重急性肝损伤伴或不伴肝衰竭的病因，但这些疾病几乎仅发生于免疫功能低下和老年患者。我们报告一例既往无病史的免疫功能正常的年轻男性病例，该患者在出现阴茎溃疡的情况下出现亚急性咳嗽和持续发热。他被发现肝功能严重升高，随后因播散性1型单纯疱疹病毒和爱泼斯坦-巴尔病毒合并感染而被诊断为噬血细胞性淋巴组织细胞增生症。他接受了静脉注射地塞米松和阿昔洛韦治疗，并完全康复。
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