Timamy Abdulmalik, Chizooma Eugine, Al-Qaysi Amina, Panourgia Maria, Ahmed Mohamed H
Department of Orthopaedic and Trauma, Milton Keynes University Hospital NHS Foundation Trust, Eaglestone, Milton Keynes, Buckinghamshire, UK.
Medical Student, Faculty of Medicine and Health Sciences, The University of Buckingham, Buckingham, UK.
J Res Med Sci. 2024 Nov 28;29:70. doi: 10.4103/jrms.jrms_277_24. eCollection 2024.
We report the case of a 72-year-old woman who was admitted following a fall and sustained a right neck of femur fracture. Prior to this admission, she was undergoing chemotherapy for lung cancer. Upon this admission, it was noted that she had developed neutropenic sepsis. She was initially treated with teicoplanin and ciprofloxacin. However, her neutrophil count dropped further, and she continued to have a high temperature, hence her treatment was switched to meropenem. Administration of meropenem was associated with persistent and difficult-to-correct hypokalemia. The hypokalemia resolved, and potassium levels returned to normal a few days after completing the course of meropenem therapy. To our knowledge, there is a very rare association between hypokalemia and the administration of meropenem. Therefore, clinicians need to be aware of this, especially in cases of refractory hypokalemia.
我们报告了一例72岁女性患者的病例，该患者因跌倒入院，发生了右侧股骨颈骨折。此次入院前，她正在接受肺癌化疗。此次入院时，发现她发生了中性粒细胞减少性败血症。她最初接受替考拉宁和环丙沙星治疗。然而，她的中性粒细胞计数进一步下降，且持续高热，因此将治疗改为美罗培南。使用美罗培南与持续性且难以纠正的低钾血症有关。低钾血症在完成美罗培南治疗疗程几天后得到缓解，血钾水平恢复正常。据我们所知，低钾血症与美罗培南的使用之间存在非常罕见的关联。因此，临床医生需要意识到这一点，尤其是在难治性低钾血症的病例中。
