Izraiq Mahmoud, Alshoubaki Nail, Abu-Dhaim Omran A, Aqel Raed
Cardiology Section, Internal Medicine Department, Specialty Hospital Amman, Jordan.
Cardiology Section, Internal Medicine Department, Istiklal Hospital Amman, Jordan.
Interv Cardiol. 2024 Nov 27;19:e25. doi: 10.15420/icr.2024.25. eCollection 2024.
Coronary artery ectasia (CAE) is an abnormal dilatation of coronary artery segments, often linked with atherosclerosis. This report discusses two cases of CAE presenting as acute coronary syndrome. A 36-year-old man had proximal blockage in the left circumflex artery (LCx) and ectasia in the obtuse marginal artery and left anterior descending artery (LAD), while a 53-year-old male smoker had an ectatic LAD with a substantial thrombus. Both were treated with dual antiplatelet therapy (aspirin and clopidogrel) and non-vitamin K antagonist oral anticoagulants (NOACs), specifically apixaban, along with atorvastatin. The first patient had complete resolution of LCx occlusion after 1 year, and the second patient had complete thrombus dissolution in the LAD in 2 months. These cases highlight the potential benefits of NOACs in managing CAE in acute coronary syndrome, suggesting that triple therapy can significantly improve clinical outcomes.
冠状动脉扩张（CAE）是冠状动脉节段的异常扩张，常与动脉粥样硬化相关。本报告讨论了两例表现为急性冠状动脉综合征的CAE病例。一名36岁男性在左旋支动脉（LCx）近端有阻塞，钝缘支动脉和左前降支动脉（LAD）有扩张，而一名53岁男性吸烟者的LAD有扩张并伴有大量血栓。两人均接受了双联抗血小板治疗（阿司匹林和氯吡格雷）以及非维生素K拮抗剂口服抗凝剂（NOACs），具体为阿哌沙班，同时服用阿托伐他汀。第一名患者在1年后LCx阻塞完全消退，第二名患者在2个月内LAD血栓完全溶解。这些病例突出了NOACs在急性冠状动脉综合征中管理CAE的潜在益处，表明三联疗法可显著改善临床结局。
