Larsson H, Valdemarsson S, Hedner P, Odeberg H
Acta Med Scand. 1985;217(1):67-72. doi: 10.1111/j.0954-6820.1985.tb01636.x.
Blood and plasma viscosity was measured in 13 patients with hypothyroidism before and during replacement therapy with l-thyroxine. Blood viscosity was measured at natural hematocrit and after adjustment to 40%. The values were compared to those of 12 healthy subjects. Both blood viscosity at hematocrit 40% and plasma viscosity were increased in the hypothyroid state and decreased to the levels of the reference group after treatment. The therapy-induced changes in blood and plasma viscosity were intercorrelated at low but not at high shear rates. The changes in viscosity were not correlated to the reductions in lipoprotein concentrations resulting from therapy. The institution of l-thyroxine replacement therapy was also followed by reductions in erythrocyte sedimentation rate and diastolic blood pressure, both with significant correlations to the decrease in blood viscosity. It is concluded that in hypothyroidism there are changes in both plasma and erythrocytes that increase blood viscosity, with normalization upon treatment with l-thyroxine to euthyroidism.
对13例甲状腺功能减退患者在使用左甲状腺素替代治疗前及治疗期间进行了血液和血浆黏度测定。在自然血细胞比容下以及将血细胞比容调整至40%后测量血液黏度。将这些值与12名健康受试者的值进行比较。在甲状腺功能减退状态下，血细胞比容为40%时的血液黏度和血浆黏度均升高，治疗后降至参考组水平。治疗引起的血液和血浆黏度变化在低剪切率下相互关联，但在高剪切率下不相关。黏度变化与治疗导致的脂蛋白浓度降低无关。左甲状腺素替代治疗开始后，红细胞沉降率和舒张压也降低，二者均与血液黏度降低显著相关。结论是，在甲状腺功能减退症中，血浆和红细胞均发生变化，导致血液黏度增加，用左甲状腺素治疗使甲状腺功能恢复正常后血液黏度恢复正常。
