Liu Xiaoyu, Liu Jia
Department of Pharmacy, Xiangyang key Laboratory of Special Preparation of Vitiligo, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China.
Biosci Microbiota Food Health. 2025;44(1):16-25. doi: 10.12938/bmfh.2024-051. Epub 2024 Aug 30.
Vitiligo is a prevalent acquired depigmenting disease that is distinguished by the depletion of functional melanocytes and epidermal melanin. Despite significant advancements in comprehending vitiligo, the precise etiology and pathogenesis of the condition remain elusive. So far, the treatment of vitiligo is still one of the most difficult dermatological challenges. Thus, developing a better understanding of vitiligo pathogenesis to develop more effective treatments is very important. Vitiligo has long been acknowledged as an autoimmune disorder, and microbes serve as crucial regulators of the immune system, exerting influences on diverse autoimmune diseases. Numerous studies have revealed the involvement of microorganisms, including bacteria and viruses, in the progression of vitiligo. This review provides a concise overview of the correlation between microbes and vitiligo, while also elucidating the potential mechanisms by which microbes may influence the development of vitiligo. The ultimate objective is to offer a comprehensive understanding of the prospects for vitiligo treatment.
白癜风是一种常见的获得性色素脱失性疾病，其特征是功能性黑素细胞和表皮黑色素减少。尽管在理解白癜风方面取得了重大进展，但该病的确切病因和发病机制仍不清楚。到目前为止，白癜风的治疗仍然是皮肤科最具挑战性的难题之一。因此，深入了解白癜风的发病机制以开发更有效的治疗方法非常重要。白癜风长期以来一直被认为是一种自身免疫性疾病，而微生物是免疫系统的关键调节因子，对多种自身免疫性疾病产生影响。许多研究已经揭示了包括细菌和病毒在内的微生物参与白癜风的进展。本综述简要概述了微生物与白癜风之间的相关性，同时阐明了微生物可能影响白癜风发展的潜在机制。最终目的是全面了解白癜风治疗的前景。
