Department of Dermatology, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, 83001, China.
Xinjiang Clinical Research Center for Dermatologic Diseases, Urumqi, 83001, China.
Oxid Med Cell Longev. 2022 Mar 14;2022:1821780. doi: 10.1155/2022/1821780. eCollection 2022.
Vitiligo is a common acquired depigmenting disease characterized by the loss of functional melanocytes and epidermal melanin. Vitiligo has a long treatment cycle and slow results, which is one of the most difficult challenges for skin diseases. Oxidative stress plays an important role as an initiating and driving factor in the pathogenesis of vitiligo. Antioxidant therapy has recently become a research hotspot in vitiligo treatment. A series of antioxidants has been discovered and applied to the treatment of vitiligo, which has returned satisfactory results. This article briefly reviews the relationship between oxidative stress and vitiligo. We also describe the progress of targeted antioxidant therapy in vitiligo, with the aim of providing a reference for new drug development and treatment options for this condition.
白癜风是一种常见的获得性色素减退性疾病，其特征是功能性黑素细胞和表皮黑色素的丧失。白癜风的治疗周期长，效果缓慢，是皮肤病中最具挑战性的难题之一。氧化应激作为白癜风发病机制中的起始和驱动因素起着重要作用。抗氧化治疗最近已成为白癜风治疗的研究热点。一系列抗氧化剂已被发现并应用于白癜风的治疗，取得了满意的效果。本文简要综述了氧化应激与白癜风的关系。我们还描述了针对抗氧化剂治疗白癜风的进展，旨在为该疾病的新药开发和治疗选择提供参考。
