Ito Juliana Tiyaki, Alves Luan Henrique Vasconcelos, Oliveira Luana de Mendonça, Xavier Rafaella Fagundes, Carvalho-Pinto Regina Maria, Tibério Iolanda de Fátima Lopes Calvo, Sato Maria Notomi, Carvalho Celso R F, Lopes Fernanda Degobbi Tenorio Quirino Dos Santos
Laboratory of Experimental Therapeutics, LIM-20, Department of Clinical Medicine, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
Laboratory of Dermatology and Immunodeficiencies, LIM-56, Department of Dermatology, Tropical Medicine Institute of Sao Paulo, School of Medicine, University of Sao Paulo, Sao Paulo, Brazil.
Pulmonology. 2025 Dec 31;31(1):2441069. doi: 10.1080/25310429.2024.2441069. Epub 2025 Jan 7.
Chronic obstructive pulmonary disease (COPD) induces an imbalance in T helper (Th) 17/regulatory T (Treg) cells that contributes to of the dysregulation of inflammation. Exercise training can modulate the immune response in healthy subjects.
We aimed to evaluate the effects of exercise training on Th17/Treg responses and the differentiation of Treg phenotypes in individuals with COPD.
This randomized controlled trial included 50 individuals with severe or very severe COPD who were allocated to the Exercise or Control groups. The Exercise group underwent eight weeks of aerobic and muscle strength training, whereas the Control group received usual care. The primary outcome was the change in the phenotypic characteristics of Tregs and Th17 profile differentiation in systemic inflammation.
Exercise training increased the frequency of total and activated Tregs and decreased the frequency of Th17 cells in between-group comparisons. Additionally, Th17/Treg responses were moderately correlated with improvements in the six-minute walking test, muscle strength of the upper and lower limbs, and daily life physical activity levels.
Exercise training improved functional exercise capacity, muscle strength, and physical fitness, which was associated with a decrease in the Th17 inflammatory response and an increase in Treg cell phenotypes immunosuppressive activity.
慢性阻塞性肺疾病（COPD）会导致辅助性T（Th）17细胞/调节性T（Treg）细胞失衡，进而导致炎症调节异常。运动训练可以调节健康受试者的免疫反应。
我们旨在评估运动训练对COPD患者Th17/Treg反应以及Treg表型分化的影响。
这项随机对照试验纳入了50名重度或极重度COPD患者，他们被分配到运动组或对照组。运动组进行了为期八周的有氧和肌肉力量训练，而对照组接受常规护理。主要结局是全身炎症中Tregs的表型特征变化和Th17谱分化。
在组间比较中，运动训练增加了总Tregs和活化Tregs的频率，并降低了Th17细胞的频率。此外，Th17/Treg反应与六分钟步行试验、上肢和下肢肌肉力量以及日常生活身体活动水平的改善呈中度相关。
运动训练改善了功能运动能力、肌肉力量和身体素质，这与Th17炎症反应的降低和Treg细胞表型免疫抑制活性的增加有关。
