Rubenstein Dana, Green Michael J, Keefe Francis J, McClernon F Joseph, Sweitzer Maggie M
Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, 2400 Pratt Street, Durham, NC 27705, United States; Clinical and Translational Science Institute, Duke University School of Medicine,Chesterfield Building, 701 W. Main St., Durham, NC 27701, United States.
Department of Obstetrics and Gynecology, Duke University School of Medicine, Duke University Medical Center 3084,203 Baker House, Durham, NC 27710, United States.
J Pain. 2025 Mar;28:104776. doi: 10.1016/j.jpain.2025.104776. Epub 2025 Jan 5.
Chronic pain affects ∼20% of the adult population and is associated with smoking. Smoking and pain worsen each other in the long term, but short-term temporal associations between smoking and pain throughout the day are unclear. Understanding these relationships may inform strategies for managing comorbid smoking and pain. Participants with chronic back pain who smoke responded to 81.5% of ecological momentary assessment (EMA) prompts delivered 5 times daily. Independent variables were: 1) urge to smoke (from 1-9), 2) intention to smoke (about to smoke, not about to smoke), and 3) smoking recency (smoked <30 min ago, smoked >30 min ago); smoking now was included as a separate category in models 2 and 3. Associations with pain intensity (from 1-9) were estimated using multi-level models, including an interaction term between the independent variable and Pain and Smoking Inventory score (PSI). Urge to smoke was associated with increased pain intensity (β=0.10 [SE=0.02], p<0.001), and this difference was greater for individuals with higher PSI scores (β=0.03 [0.01], p=0.003). Not being about to smoke was associated with lower pain intensity than smoking now (β=-0.29 [0.09], p=0.001). Compared to smoking now, both smoking <30 min ago (β=-0.30 [0.09], p=0.001) and smoking >30 min ago (β=-0.23 [0.11], p=0.029) were associated with lower pain intensity. Smoking urges may increase pain intensity (or vice versa), especially when people perceive strong relationships between smoking and pain. Smoking may also attenuate perceived pain. Further research is needed on interventions that combine tailored smoking cessation treatments and behavioral pain management strategies. PERSPECTIVE: This analysis of momentary data reported throughout the day by people with back pain who smoke revealed novel insights into short-term relationships between pain and smoking. Study results can inform future treatment development for individuals with chronic pain who smoke.
慢性疼痛影响约20%的成年人口,且与吸烟有关。从长期来看,吸烟和疼痛会相互加重,但一天中吸烟与疼痛之间的短期时间关联尚不清楚。了解这些关系可能为管理吸烟与疼痛共病的策略提供依据。患有慢性背痛且吸烟的参与者对每天5次的生态瞬时评估(EMA)提示做出了81.5%的回应。自变量包括:1)吸烟冲动(1至9级),2)吸烟意图(即将吸烟、不会吸烟),以及3)最近吸烟情况(30分钟内吸烟、30分钟前吸烟);在模型2和3中,当前吸烟被列为一个单独类别。使用多层次模型估计与疼痛强度(1至9级)的关联,模型中包括自变量与疼痛和吸烟量表评分(PSI)之间的交互项。吸烟冲动与疼痛强度增加相关(β=0.10[标准误=0.02],p<0.001),且PSI评分较高的个体这种差异更大(β=0.03[0.01],p=0.003)。与当前吸烟相比,不会吸烟与较低的疼痛强度相关(β=-0.29[0.09],p=0.001)。与当前吸烟相比,30分钟内吸烟(β=-0.30[0.09],p=0.001)和30分钟前吸烟(β=-0.23[0.11],p=0.029)均与较低的疼痛强度相关。吸烟冲动可能会增加疼痛强度(反之亦然),尤其是当人们认为吸烟与疼痛之间存在密切关系时。吸烟也可能减轻感知到的疼痛。需要对结合定制戒烟治疗和行为疼痛管理策略的干预措施进行进一步研究。观点:对吸烟的背痛患者全天报告的瞬时数据进行的这项分析揭示了疼痛与吸烟之间短期关系的新见解。研究结果可为吸烟的慢性疼痛个体的未来治疗发展提供参考。