Tobias Joshua, Heinl Stefan, Dendinovic Kristina, Ramić Ajša, Schmid Anna, Daniel Catherine, Wiedermann Ursula
Institute of Specific Prophylaxis and Tropical Medicine, Center for Pathophysiology, Infectiology and Immunology, Medical University of Vienna, Vienna, Austria.
Institute of Molecular Biotechnology, Department of Biotechnology, University of Natural Resources and Life Sciences, Vienna, Austria.
Immunol Lett. 2025 Apr;272:106971. doi: 10.1016/j.imlet.2025.106971. Epub 2025 Jan 5.
Probiotics have been increasingly recognized for positively influencing many aspects of human health. Lactiplantibacillus plantarum (L. plantarum), a non-pathogenic bacterium, previously known as Lactobacillus plantarum, is one of the lactic acid bacteria commonly used in fermentation. The probiotic properties of L. plantarum have highlighted its health benefits to humans when consumed in adequate amounts. L. plantarum strains primarily enter the body orally and alter intestinal microflora and modulate the immune responses in their host; thereby benefiting human health. Furthermore, the use of L. plantarum as vaccine vectors delivering mucosal antigens has been shown to be a promising strategy. These aspects, from Immunomodulation to vaccine delivery by L. plantarum in preclinical settings, are highlighted in this review. Along these lines, construction of a recombinant L. plantarum strain expressing a B cell multi-peptide, as a future vaccine to modulate immunity and confer anti-tumor effect by targeting Her-2/neu-overexpressing cancers in local and distal sites, is also presented and discussed.
益生菌对人类健康的诸多方面产生积极影响，这一点已得到越来越多的认可。植物乳杆菌（L. plantarum）是一种非致病性细菌，以前称为嗜酸乳杆菌，是发酵中常用的乳酸菌之一。植物乳杆菌的益生菌特性突出了其适量食用时对人类健康的益处。植物乳杆菌菌株主要通过口服进入人体，改变肠道微生物群并调节宿主的免疫反应，从而有益于人类健康。此外，将植物乳杆菌用作递送粘膜抗原的疫苗载体已被证明是一种有前景的策略。本综述重点介绍了这些方面，从临床前环境中植物乳杆菌的免疫调节到疫苗递送。沿着这些思路，还介绍并讨论了构建表达B细胞多肽的重组植物乳杆菌菌株，作为一种未来的疫苗，通过靶向局部和远处位点过表达Her-2/neu的癌症来调节免疫并赋予抗肿瘤作用。
