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代谢与减重手术后大麻的使用:文献综述

Cannabis use before and after metabolic and bariatric surgery: literature review.

作者信息

Goodpaster Kasey P S, Brown Rheanna Ata, Van Prooyen Amanda M, Chapmon Katie, Santos Melissa, Crispell Gwen, Sarwer David B

机构信息

Cleveland Clinic Bariatric & Metabolic Institute, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio.

Cleveland Clinic Bariatric & Metabolic Institute, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio.

出版信息

Surg Obes Relat Dis. 2025 Apr;21(4):345-353. doi: 10.1016/j.soard.2024.12.006. Epub 2024 Dec 15.

Abstract

As accessibility and legalization of cannabis rise throughout the United States (US), programs have sought guidance about whether its use should be considered a contraindication or, if not a contraindication, what recommendations patients should receive regarding appropriate use before and after metabolic and bariatric surgery (MBS). In this review, medical, nutritional, pharmacological, and psychological considerations are presented by a multidisciplinary group of members of the American Society for Metabolic and Bariatric Surgery (ASMBS). Research suggests several risks associated with long-term cannabis use in the general population, but research in the MBS population, specifically, is limited. Cannabis use is not associated with most postoperative complications but is associated with mental health concerns and disordered eating in patients who have undergone MBS. Research regarding weight loss outcomes is mixed, with most studies showing no significant association. Severe cannabis use appears to have more clinical significance than mild to moderate use, as it is associated with longer lengths of stay and medical complications. While an active cannabis use disorder is considered a contraindication, requiring treatment and abstinence before proceeding with surgery, the state of the literature is not strong enough to suggest that occasional or medical cannabis use is an absolute contraindication to MBS. Decisions about cannabis protocols should be made at the MBS program level, and patients should be fully informed about the risks of ongoing use.

摘要

随着大麻在美国的可及性和合法化程度不断提高,一些项目一直在寻求指导意见,即大麻使用是否应被视为代谢和减重手术(MBS)的禁忌证;如果不是禁忌证,那么对于接受MBS手术的患者,在手术前后的适当使用方面应给予哪些建议。在本综述中,美国代谢和减重外科学会(ASMBS)的多学科成员介绍了医学、营养、药理学和心理学方面的考虑因素。研究表明,普通人群长期使用大麻存在多种风险,但针对MBS人群的具体研究有限。大麻使用与大多数术后并发症无关,但与接受MBS手术的患者的心理健康问题和饮食紊乱有关。关于减肥效果的研究结果不一,大多数研究表明无显著关联。重度大麻使用似乎比轻度至中度使用具有更大的临床意义,因为它与住院时间延长和医疗并发症有关。虽然活跃的大麻使用障碍被视为禁忌证,需要在手术前进行治疗并戒除,但现有文献的证据强度不足以表明偶尔使用或医用大麻是MBS的绝对禁忌证。关于大麻使用方案的决策应在MBS项目层面做出,并且应让患者充分了解持续使用大麻的风险。

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