Kim Seung-Hyun, Yoo Dae Sung, Park Chul-Ho, Lee Sang-Ho, Lee Ju-Hwan, Ahn Taeho, Jung Bock-Gie, Park Jun-Gyu, Park Sang-Ik, Bae Chun-Sik
Department of Veterinary Surgery, College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of Korea.
College of Veterinary Medicine, Chonnam National University, Gwangju 61186, Republic of Korea.
Animals (Basel). 2024 Dec 20;14(24):3687. doi: 10.3390/ani14243687.
The incidence of mammary gland tumors in dogs is a significant issue, characterized by notable rates of malignancy, recurrence, and disease burden. However, the lack of comprehensive information and correlated studies has presented challenges in establishing an effective surgical treatment strategy. In this study, a cohort of 95 dogs diagnosed with mammary tumors underwent evaluation using various surgical methods, medications, ovariohysterectomy, and assessments of margin completeness to analyze clinical outcomes. Significant clinical outcomes were observed following radical mastectomy and conservative surgeries, irrespective of TNM stages and histopathological grade of malignancy. Complete excision demonstrated significantly improved survival time and disease-free interval compared to incomplete excision. It is noted that complete surgical excision provides benefits, even in cases where lymphatic invasion is present. However, further investigations are necessary to validate the clinical results and mitigate side effects from radical mastectomy. Despite postoperative complications, several studies continue to advocate for more radical mastectomies due to their favorable risk-benefit ratio. Moreover, advanced inpatient treatments can now effectively manage or mitigate many of these complications. This study emphasizes the critical role of surgical proficiency and postoperative medication in treating malignant mammary tumors in dogs, and it provides insights that may contribute to the development of more effective treatment strategies for this condition.
犬乳腺肿瘤的发病率是一个重要问题，其特点是恶性率、复发率和疾病负担都很高。然而，由于缺乏全面的信息和相关研究，在制定有效的手术治疗策略方面面临挑战。在本研究中，对95只被诊断患有乳腺肿瘤的犬进行了评估，采用了各种手术方法、药物治疗、卵巢子宫切除术，并对切缘完整性进行了评估，以分析临床结果。无论TNM分期和组织病理学恶性程度如何，根治性乳房切除术和保守性手术之后均观察到了显著的临床效果。与不完全切除相比，完全切除显示出生存时间和无病间期有显著改善。需要注意的是，即使存在淋巴浸润的情况，完全手术切除也有好处。然而，需要进一步研究来验证临床结果并减轻根治性乳房切除术的副作用。尽管有术后并发症，但由于其有利的风险效益比，一些研究仍继续主张进行更根治性的乳房切除术。此外，先进的住院治疗现在可以有效地管理或减轻许多此类并发症。本研究强调了手术熟练程度和术后药物治疗在治疗犬恶性乳腺肿瘤中的关键作用，并提供了可能有助于制定针对这种情况的更有效治疗策略的见解。
