Robinson J L, Dombrowski D B, Tauss L R, Jones L R
Am J Clin Nutr. 1985 Mar;41(3):605-8. doi: 10.1093/ajcn/41.3.605.
The hypolipidemia induced by oral orotic acid in rats but not in other experimental species was investigated in human adults. Twelve outpatients in a medically-supervised weight reduction program participated in the study. After adaptation to their restricted dietary regime for at least 8 weeks, all subjects were given placebos (1 g lactose/day) for 2 weeks, then orotic acid (1 g/day) for 4 weeks, followed by placebos for 2 more weeks. Pertinent dietary, urinary, and serum parameters were monitored biweekly and intake of calories, carbohydrate, protein and fat was similar throughout. The ingestion of orotic acid did not lower serum triglycerides or cholesterol in these subjects. Since the daily dose tested corresponds to the orotic acid in 12 liters of cow's milk, milk orotic acid at levels normally consumed should not be considered a hypolipidemic or hypocholesteremic agent for humans.
在人类成年人中研究了口服乳清酸在大鼠而非其他实验物种中所诱导的低脂血症。一个医学监督下的减肥项目中的12名门诊患者参与了该研究。在适应至少8周的限制饮食方案后，所有受试者服用安慰剂（1克乳糖/天）2周，然后服用乳清酸（1克/天）4周，接着再服用安慰剂2周。每两周监测相关的饮食、尿液和血清参数，并且整个过程中卡路里、碳水化合物、蛋白质和脂肪的摄入量相似。在这些受试者中，摄入乳清酸并未降低血清甘油三酯或胆固醇。由于所测试的每日剂量相当于12升牛奶中的乳清酸，正常摄入水平的牛奶乳清酸不应被视为人类的降血脂或降胆固醇剂。
