Alexandru Isaic, Nistor Daciana, Motofelea Alexandru Catalin, Cadar Andone Bianca-Astrid, Crintea Andreea, Tatu Carmen, Pop Gheorghe Nicusor, Csep Andrei Nicolae
Department of General Surgery, "Victor Babes" University of Medicine and Pharmacy Timisoara, Eftimie Murgu Square 2, 300041 Timisoara, Romania.
Department of Functional Sciences, Physiology, Centre of Imuno-Physiology and Biotechnologies (CIFBIOTEH), "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Antioxidants (Basel). 2024 Dec 19;13(12):1567. doi: 10.3390/antiox13121567.
Gynecological cancers, including ovarian, cervical, and endometrial cancers, significantly affect both survival and reproductive health in women. Cancer treatments such as chemotherapy and radiotherapy can impair ovarian function, reducing oocyte quality and fertility potential.
This review aims to evaluate how vitamins and antioxidants can enhance fertility and fertility preservation outcomes for women diagnosed with gynecological cancers, particularly in the context of assisted reproductive technologies (ART). Standard treatments for these cancers, including hysterectomy, bilateral salpingo-oophorectomy, radiation, and chemotherapy, often compromise ovarian function and oocyte quality. This review focuses on the potential role of these interventions in improving oocyte quality, thereby supporting successful fertility preservation and ART outcomes.
A comprehensive narrative review of the current literature was conducted, examining the effects of vitamins A, C, D3, E, and Coenzyme Q10 on oocyte quality, particularly in the context of oxidative stress and inflammation induced by cancer and its treatments.
The evidence suggests that certain vitamins and antioxidants may mitigate oxidative damage and enhance oocyte quality. Vitamin A supports cumulus-oocyte complex integrity, while vitamins C and E act as potent antioxidants, reducing oxidative stress in ovarian tissues. Vitamin D3 enhances ovarian reserve markers and modulates inflammatory cytokines. Coenzyme Q10 improves mitochondrial function and reduces DNA damage, increasing oocyte viability and fertilization potential.
The incorporation of specific vitamins and antioxidants into fertility preservation strategies may enhance oocyte quality in women with gynecological cancers. Although the preliminary findings are promising, further research is needed to determine optimal dosages and establish standardized protocols for clinical use.
妇科癌症，包括卵巢癌、宫颈癌和子宫内膜癌，对女性的生存和生殖健康均有显著影响。化疗和放疗等癌症治疗方法会损害卵巢功能，降低卵母细胞质量和生育潜力。
本综述旨在评估维生素和抗氧化剂如何提高被诊断为妇科癌症的女性的生育能力以及生育力保存效果，特别是在辅助生殖技术（ART）背景下。这些癌症的标准治疗方法，包括子宫切除术、双侧输卵管卵巢切除术、放疗和化疗，常常会损害卵巢功能和卵母细胞质量。本综述聚焦于这些干预措施在改善卵母细胞质量方面的潜在作用，从而支持成功的生育力保存和ART结局。
对当前文献进行了全面的叙述性综述，研究维生素A、C、D3、E和辅酶Q10对卵母细胞质量的影响，特别是在癌症及其治疗引发的氧化应激和炎症背景下。
证据表明某些维生素和抗氧化剂可能减轻氧化损伤并提高卵母细胞质量。维生素A支持卵丘-卵母细胞复合体的完整性，而维生素C和E作为强效抗氧化剂，可减轻卵巢组织中的氧化应激。维生素D3可提高卵巢储备指标并调节炎性细胞因子。辅酶Q10可改善线粒体功能并减少DNA损伤，提高卵母细胞活力和受精潜力。
在生育力保存策略中加入特定的维生素和抗氧化剂可能会提高妇科癌症女性的卵母细胞质量。尽管初步研究结果很有前景，但仍需要进一步研究以确定最佳剂量并建立临床使用的标准化方案。
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