Hung Yu-Tun, Yu Tsong-Han, Alizargar Javad
Department of Orthopedics Surgery, Department of Medicine, Hualien Armed Forces General Hospital, Hualien 971, Taiwan.
Department of Orthopedics, Tri-Service General Hospital, National Defense Medical Center, Taipei City 114, Taiwan.
Healthcare (Basel). 2024 Dec 11;12(24):2502. doi: 10.3390/healthcare12242502.
The association between insulin resistance (IR) and bone mineral density (BMD) remains contentious. The aim of this study is to assess the predictive capability of the Triglyceride and Glucose (TyG) index concerning changes in bone mineral density, encompassing both deterioration and improvement. This study analyzed data from the UK Biobank, encompassing 2527 participants after exclusions. Logistic models and ANOVA were employed, with propensity score matching addressing the effects of age, BMI, and sex. The TyG index was calculated using this formula: Ln (triglyceride [mg/dL] × glucose [mg/dL]/2). Initially, a positive correlation was observed between the TyG index and BMD measures. However, upon adjustment for age, sex, and BMI, this association lost significance. Propensity score matching further indicated no inverse relationship between the TyG index and osteoporosis development. Although the TyG index demonstrated a positive correlation with BMD, caution is warranted due to potential confounding by age, sex, and BMI. Notably, the TyG index alone did not predict changes in T-score or osteoporosis status.
胰岛素抵抗（IR）与骨密度（BMD）之间的关联仍存在争议。本研究的目的是评估甘油三酯与葡萄糖（TyG）指数对骨密度变化（包括恶化和改善）的预测能力。本研究分析了英国生物银行的数据，排除后共有2527名参与者。采用了逻辑模型和方差分析，并通过倾向得分匹配来处理年龄、体重指数和性别的影响。TyG指数使用以下公式计算：Ln（甘油三酯[mg/dL]×葡萄糖[mg/dL]/2）。最初，观察到TyG指数与骨密度测量值之间存在正相关。然而，在对年龄、性别和体重指数进行调整后，这种关联失去了显著性。倾向得分匹配进一步表明TyG指数与骨质疏松症的发生之间没有负相关关系。尽管TyG指数与骨密度呈正相关，但由于年龄、性别和体重指数可能存在混杂因素，仍需谨慎。值得注意的是，仅TyG指数并不能预测T评分或骨质疏松症状态的变化。
