Department of Orthopaedics, Lanzhou University Second Hospital, #82 Cuiyingmen, Lanzhou, 730000, Gansu, China.
Orthopaedic Clinical Research Center of Gansu Province, Lanzhou, Gansu, China.
Arch Osteoporos. 2024 May 25;19(1):42. doi: 10.1007/s11657-024-01395-2.
This study examines the relationship between TyG-BMI, an indicator of insulin resistance, and bone mineral density in US adults without diabetes, revealing a positive association. The findings suggest that higher TyG-BMI levels may be linked to a lower risk of osteoporosis, providing a basis for future research in this area.
Patients with osteoporosis are often diagnosed with type 2 diabetes or prediabetes. Insulin resistance is a prediabetic state, and triglyceride glucose-body mass index (TyG-BMI) has been recognized as a potential predictor of it, valuable in assessing prediabetes, atherosclerosis, and other diseases. However, the validity of TyG-BMI in osteoporosis studies remains inadequate.
The purpose of this study was to evaluate the relationship between TyG-BMI and BMD as well as the effect of TyG-BMI on the odds of developing osteoporosis in US adults without diabetes.
National Health and Nutrition Examination Survey data were obtained. The relationship between TyG-BMI and BMD was evaluated via multivariate linear regression models. Smoothed curve fitting and threshold effect analysis explored potential non-linear relationships, and age, gender, and race subgroup analyses were performed. In addition, multivariate logistic regression models were employed to analyze its potential role in the development of osteoporosis.
In a study of 6501 participants, we observed a significant positive correlation between the TyG-BMI index and BMD, even after adjusting for covariates and categorizing TyG-BMI. The study identified specific TyG-BMI folding points-112.476 for the total femur BMD, 100.66 for the femoral neck BMD, 107.291 for the intertrochanter BMD, and 116.58 for the trochanter BMD-indicating shifts in the relationship's strength at these thresholds. While the association's strength slightly decreased after the folding points, it remained significant. Subgroup analyses further confirmed the positive TyG-BMI and BMD correlation. Multivariate linear regression analyses indicated a lower osteoporosis risk in participants with higher TyG-BMI levels, particularly in menopausal women over 40 and men over 60.
This study suggests a positive correlation between BMD and TyG-BMI in US adults without diabetes. Individuals with higher levels of TyG-BMI may have a lower risk of osteoporosis.
患有骨质疏松症的患者常被诊断患有 2 型糖尿病或糖尿病前期。胰岛素抵抗是一种糖尿病前期状态，甘油三酯葡萄糖-体重指数（TyG-BMI）已被认为是其潜在的预测指标，在评估糖尿病前期、动脉粥样硬化和其他疾病方面具有重要价值。然而，TyG-BMI 在骨质疏松症研究中的有效性仍然不足。
本研究旨在评估 TyG-BMI 与 BMD 之间的关系，以及 TyG-BMI 对美国无糖尿病成年人骨质疏松症发病风险的影响。
我们使用美国国家健康与营养调查（NHANES）数据。采用多元线性回归模型评估 TyG-BMI 与 BMD 之间的关系。采用平滑曲线拟合和阈值效应分析探讨潜在的非线性关系，并进行年龄、性别和种族亚组分析。此外，我们还采用多元逻辑回归模型分析其在骨质疏松症发生中的潜在作用。
在一项对 6501 名参与者的研究中，我们观察到 TyG-BMI 指数与 BMD 之间存在显著的正相关关系，即使在调整了协变量并对 TyG-BMI 进行分类后也是如此。研究确定了特定的 TyG-BMI 折叠点-总股骨 BMD 为 112.476，股骨颈 BMD 为 100.66，转子间 BMD 为 107.291，转子下 BMD 为 116.58-这些阈值表明关系强度的变化。虽然折叠点后关联的强度略有下降，但仍具有统计学意义。亚组分析进一步证实了 TyG-BMI 和 BMD 之间的正相关关系。多元线性回归分析表明，TyG-BMI 水平较高的参与者骨质疏松症发病风险较低，尤其是 40 岁以上的绝经后女性和 60 岁以上的男性。
本研究表明，在美国无糖尿病成年人中，BMD 与 TyG-BMI 之间存在正相关关系。TyG-BMI 水平较高的个体可能患骨质疏松症的风险较低。
