Alexandru Alexandru, Ivan Cristiana-Smaranda, Tanasescu Sonia, Oprisoni Licina Andrada, Dragomir Tiberiu-Liviu, Varga Norberth-Istvan, Mateescu Diana, Diaconu Mircea, Margan Madalin-Marius, Boeriu Estera
Department of General Medicine, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania.
Department of Pediatrics, "Victor Babes" University of Medicine and Pharmacy, Eftimie Murgu Square 2, 300041 Timisoara, Romania.
Cancers (Basel). 2024 Dec 17;16(24):4201. doi: 10.3390/cancers16244201.
: Vitamin D deficiency is increasingly recognized as a global health concern, with potential implications for cancer development and progression. This systematic review investigated the prevalence of vitamin D deficiency in pediatric cancer patients and its potential impact on clinical outcomes. : A comprehensive literature search was conducted across multiple databases, including PubMed, Web of Science, and Cochrane Library, to identify the relevant studies published between 2009 and July 2024. Studies were included if they assessed vitamin D status in pediatric cancer patients and reported on the clinical outcomes. Data extraction and quality assessment were performed independently by two reviewers. : The review included 20 original articles encompassing a diverse pediatric population with various cancer types. A high prevalence of vitamin D deficiency was observed across the studies. Deficiency was associated with older age and lower socioeconomic status. Several studies reported associations between vitamin D deficiency and the increased risk of infection, poorer treatment response, and decreased survival. : Vitamin D deficiency is highly prevalent in pediatric cancer patients and may negatively impact clinical outcomes. Routine screening for vitamin D deficiency and personalized supplementation strategies should be considered in this population. Further research is needed to establish optimal vitamin D management protocols and evaluate the long-term benefits of vitamin D repletion in pediatric oncology.
维生素D缺乏日益被视为一个全球健康问题，对癌症的发生和发展可能产生影响。本系统评价调查了儿科癌症患者中维生素D缺乏的患病率及其对临床结局的潜在影响。：在多个数据库中进行了全面的文献检索，包括PubMed、科学网和Cochrane图书馆，以确定2009年至2024年7月期间发表的相关研究。如果研究评估了儿科癌症患者的维生素D状况并报告了临床结局，则纳入研究。由两名审阅者独立进行数据提取和质量评估。：该评价纳入了20篇原创文章，涵盖了患有各种癌症类型的不同儿科人群。在各项研究中均观察到维生素D缺乏的高患病率。缺乏与年龄较大和社会经济地位较低有关。几项研究报告了维生素D缺乏与感染风险增加、治疗反应较差和生存率降低之间的关联。：维生素D缺乏在儿科癌症患者中非常普遍，可能对临床结局产生负面影响。应考虑对该人群进行维生素D缺乏的常规筛查和个性化补充策略。需要进一步研究以建立最佳的维生素D管理方案，并评估维生素D补充在儿科肿瘤学中的长期益处。
