CXCL13作为一种生物标志物：在多发性硬化症中的背景与应用
CXCL13 as a Biomarker: Background and Utility in Multiple Sclerosis.
作者信息
Pachner Andrew R, Pike Steven, Smith Andrew D, Gilli Francesca
机构信息
Geisel School of Medicine at Dartmouth, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756, USA.
出版信息
Biomolecules. 2024 Nov 30;14(12):1541. doi: 10.3390/biom14121541.
Abstract
CXCL13 is a chemokine which is upregulated within the CNS in multiple sclerosis, Lyme neuroborreliosis, and other inflammatory diseases and is increasingly clinically useful as a biomarker. This review provides background for understanding its function in the immune system and its relationship to ectopic lymphoid follicles. Also reviewed are its utility in multiple sclerosis and Lyme neuroborreliosis and potential problems in its measurement. CXCL13 has the potential to be an exceptionally useful biomarker in a range of inflammatory diseases.
摘要
CXCL13是一种趋化因子，在多发性硬化症、莱姆病性神经疏螺旋体病和其他炎症性疾病的中枢神经系统中上调，并且作为一种生物标志物在临床上越来越有用。本综述为理解其在免疫系统中的功能及其与异位淋巴滤泡的关系提供了背景。还综述了其在多发性硬化症和莱姆病性神经疏螺旋体病中的应用以及测量中的潜在问题。CXCL13有可能成为一系列炎症性疾病中一种极其有用的生物标志物。
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