Lacerda Guilherme J M, Camargo Lucas, Imamura Marta, Marques Lucas M, Battistella Linamara, Fregni Felipe
Instituto de Medicina Física e Reabilitação, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo 05403-010, SP, Brazil.
Neuromodulation Center and Center for Clinical Research Learning, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard Medical School, Boston, MA 02115, USA.
Brain Sci. 2024 Dec 7;14(12):1229. doi: 10.3390/brainsci14121229.
Spinal cord injury (SCI) affects approximately 250,000 to 500,000 individuals annually. Current therapeutic interventions predominantly focus on mitigating the impact of physical and neurological impairments, with limited functional recovery observed in many patients. Electroencephalogram (EEG) oscillations have been investigated in this context of rehabilitation to identify effective markers for optimizing rehabilitation treatments.
We performed an exploratory cross-sectional study assessing the baseline EEG resting state of 86 participants with SCI as part of the Deficit of Inhibitory as a Marker of Neuroplasticity in Rehabilitation Cohort Study (DEFINE).
Our multivariate models demonstrated a positive correlation between frontal delta asymmetry and depression symptoms, while the frontal alpha asymmetry band and anxiety symptoms were negatively correlated. Theta oscillations were negatively associated with motor-evoked potential (MEP), whereas alpha oscillations were positively associated with MEP in all regions of interest and with CPM response as a negative correlation. Based on the potential role of lower-frequency oscillations in exerting a salutogenic compensatory effect, detrimental clinical and neurophysiological markers, such as depression and lower ME, likely induce slow oscillatory rhythms. Alpha oscillations may indicate a more salutogenic state, often associated with various cognitive functions, such as attention and memory processing.
These results show an attempt by the CNS to reorganize and restore function despite the disruption caused by SCI. Indeed, this finding also challenges the notion that low-frequency EEG rhythms are associated with cortical lesions. These results may contribute to the development of rehabilitation strategies and potentially improve the clinical outcomes of patients with SCI.
脊髓损伤（SCI）每年影响约25万至50万人。目前的治疗干预主要集中在减轻身体和神经损伤的影响，许多患者的功能恢复有限。在这种康复背景下，已经对脑电图（EEG）振荡进行了研究，以确定优化康复治疗的有效标志物。
作为“康复队列研究中抑制缺陷作为神经可塑性标志物”（DEFINE）的一部分，我们进行了一项探索性横断面研究，评估了86名脊髓损伤参与者的基线脑电图静息状态。
我们的多变量模型显示额叶δ波不对称与抑郁症状呈正相关，而额叶α波不对称带与焦虑症状呈负相关。θ振荡与运动诱发电位（MEP）呈负相关，而α振荡在所有感兴趣区域与MEP呈正相关，与连续性能测试（CPM）反应呈负相关。基于低频振荡在发挥有益健康的代偿作用方面的潜在作用，有害的临床和神经生理学标志物，如抑郁和较低的运动诱发电位，可能会诱发缓慢的振荡节律。α振荡可能表明一种更有益健康的状态，通常与各种认知功能相关，如注意力和记忆处理。
这些结果表明，尽管脊髓损伤造成了破坏，但中枢神经系统仍试图进行重组和恢复功能。事实上，这一发现也挑战了低频脑电图节律与皮质病变相关的观念。这些结果可能有助于制定康复策略，并有可能改善脊髓损伤患者的临床结局。
