Qiu Lei, Ma Zelong, Wu Xiaoming
Laboratory of Molecular Genetics of Aging & Tumor, Medical School, Kunming University of Science and Technology, Chenggong Campus, 727 South Jingming Road, Kunming 650500, China.
Genes (Basel). 2024 Dec 17;15(12):1615. doi: 10.3390/genes15121615.
The tumor secretome comprises the totality of protein factors secreted by various cell components within the tumor microenvironment, serving as the primary medium for signal transduction between tumor cells and between tumor cells and stromal cells. The deletion or mutation of the gene leads to alterations in cellular secretion characteristics, contributing to the construction of the tumor microenvironment in a cell non-autonomous manner. This review discusses the critical roles of mutant p53 in regulating the tumor secretome to remodel the tumor microenvironment, drive tumor progression, and influence the plasticity of cancer-associated fibroblasts (CAFs) as well as the dynamics of tumor immunity by focusing on both secreted protein expression and secretion pathways. The aim is to provide new insights for targeted cancer therapies.
肿瘤分泌组包含肿瘤微环境中各种细胞成分分泌的全部蛋白质因子，是肿瘤细胞之间以及肿瘤细胞与基质细胞之间信号转导的主要介质。该基因的缺失或突变会导致细胞分泌特征的改变，以非细胞自主方式参与肿瘤微环境的构建。本综述通过聚焦分泌蛋白表达和分泌途径，探讨突变型p53在调节肿瘤分泌组以重塑肿瘤微环境、驱动肿瘤进展以及影响癌症相关成纤维细胞（CAF）的可塑性和肿瘤免疫动力学方面的关键作用。目的是为靶向癌症治疗提供新的见解。
