Butucescu Mihai, Imre Marina, Rus-Hrincu Florentina, Voicu-Balasea Bianca, Popa Alexandra, Moisa Mihai, Ripszky Alexandra, Neculau Cristina, Pituru Silviu Mirel, Pârvu Simona
Department of Organization, Professional Legislation and Management of the Dental Office, Faculty of Dental Medicine, "Carol Davila" University of Medicine and Pharmacy, 17-23 Plevnei Street, 020021 Bucharest, Romania.
Department of Prosthodontics, Faculty of Dental Medicine, "Carol Davila" University of Medicine and Pharmacy, 17-23 Calea Plevnei, 010221 Bucharest, Romania.
Diagnostics (Basel). 2024 Dec 11;14(24):2784. doi: 10.3390/diagnostics14242784.
Periimplantitis represents an inflammatory disease of the soft and hard tissues surrounding the osseointegrated dental implant, triggering progressive damage to the alveolar bone. Cumulative data have revealed that periimplantitis plays a crucial part in implant failure. Due to the strategic roles of autophagy and its upstream coordinator, the AKT/mTOR pathway, in inflammatory responses, the crosstalk between them in the context of periimplantitis should become a key research target, as it opens up an area of interesting data with clinical significance. Therefore, in this article, we aimed to briefly review the existing data concerning the complex roles played by ROS in the interplay between the AKT/mTOR signaling pathway and autophagy in periimplantitis, in each of the main cell types involved in periimplantitis pathogenesis and evolution. Knowing how to modulate specifically the autophagic machinery in each of the cellular types involved in the healing and osseointegration steps post implant surgery can help the clinician to make the most appropriate post-surgery decisions. These decisions might be crucial in order to prevent the occurrence of periimplantitis and ensure the proper conditions for effective osseointegration, depending on patients' clinical particularities.
种植体周围炎是一种发生在骨结合牙种植体周围软硬组织的炎症性疾病，会引发牙槽骨的渐进性破坏。累积数据表明，种植体周围炎在种植体失败中起着关键作用。由于自噬及其上游协调因子AKT/mTOR信号通路在炎症反应中具有重要作用，它们在种植体周围炎背景下的相互作用应成为关键研究靶点，因为这开辟了一个具有临床意义的有趣数据领域。因此，在本文中，我们旨在简要回顾现有数据，这些数据涉及活性氧（ROS）在种植体周围炎发病机制和发展过程中，在参与其中的每种主要细胞类型里，在AKT/mTOR信号通路与自噬之间的相互作用中所起的复杂作用。了解如何在种植手术后的愈合和骨结合步骤中，特异性调节每种参与细胞类型中的自噬机制，有助于临床医生做出最合适的术后决策。根据患者的临床特点，这些决策对于预防种植体周围炎的发生以及确保有效骨结合的适当条件可能至关重要。
