Forni Riccardo, Gargiulo Paolo, Boretti Gabriele, Quadrelli Marco, Baccaglini Tommaso, Morra Aldo, Ravara Barbara, Zampieri Sandra, Pond Amber, Carraro Ugo, Maccarone Maria Chiara, Masiero Stefano
Institute of Biomedical and Neural Engineering, Reykjavik University, 101 Reykjavik, Iceland.
Landspitali, University Hospital of Iceland, 101 Reykjavik, Iceland.
Diagnostics (Basel). 2024 Dec 13;14(24):2808. doi: 10.3390/diagnostics14242808.
Background and Clinical Significance: Sarcopenia, characterized by muscle loss and fat infiltration, poses a significant health burden for aging populations. Quantitative Color 2D and 3D radiodensitometry provides a powerful tool to monitor muscle quality and quantity through CT imaging. This study assessed the impact of a ten-year-long home-bed gym exercise intervention on muscle quality in an elderly subject using CT-derived radiodensitometric analysis. The study involved two comparative analyses: Study A, which compared knee-to-ankle CT scans of the subject between 2013 and 2023; and Study B, which compared the subject's 2023 thigh CT scan with a cohort of 2500 elderly Icelandic individuals from the AGES-Reykjavik study.
A 70-year-old male began a home-based Full-Body In-Bed Gym exercise program in 2013. Quantitative muscle volume and radiodensity measurements were performed using CT at baseline and after ten years.
Study A shows significant improvements in muscle volume observed in the knee-to-ankle region, while a slower decline in radiodensity was noted, indicating substantial preservation of muscle quality despite the expected decay of ten-year aging. For instance, muscle volume increased by 15% in the left Soleus muscle and by 6% in the right Soleus muscle, while the average radiodensity decreased by 12-17 HU. The subject's thigh muscle quality at 80-years-old is above the AGES-Reykjavik's cohort average, with reduced fat infiltration.
Long-term home Full-Body In-Bed Gym, a low-impact exercise, can mitigate aging sarcopenia, as evidenced by improved tissue radiodensity and muscle mass substantial preservation. This suggests potential applications in personalized healthcare strategies to enhance muscle preservation among aging populations.
背景与临床意义：肌肉减少症以肌肉流失和脂肪浸润为特征，给老年人群带来了重大的健康负担。定量彩色二维和三维放射密度测定法通过CT成像提供了一个监测肌肉质量和数量的有力工具。本研究使用CT衍生的放射密度分析评估了为期十年的居家床上健身运动干预对一名老年受试者肌肉质量的影响。该研究涉及两项比较分析：研究A，比较了该受试者在2013年至2023年期间的膝至踝关节CT扫描；研究B，将该受试者2023年的大腿CT扫描与来自AGES-雷克雅未克研究的2500名冰岛老年个体队列进行了比较。
一名70岁男性于2013年开始了一项居家全身床上健身运动计划。在基线和十年后使用CT进行了定量肌肉体积和放射密度测量。
研究A显示，膝至踝关节区域的肌肉体积有显著改善，同时放射密度下降较慢，这表明尽管经历了十年的预期衰老，但肌肉质量仍得到了大量保留。例如，左侧比目鱼肌的肌肉体积增加了15%，右侧比目鱼肌增加了6%，而平均放射密度下降了12 - 17 HU。该受试者80岁时的大腿肌肉质量高于AGES-雷克雅未克队列的平均水平，脂肪浸润减少。
长期居家全身床上健身运动，一种低冲击力的运动，可以减轻衰老性肌肉减少症，组织放射密度的改善和肌肉质量的大量保留证明了这一点。这表明在个性化医疗保健策略中具有潜在应用，以增强老年人群的肌肉保留。
