Pérez-Bermejo Marcelino, Barrezueta-Aguilar Cristian, Pérez-Murillo Javier, Ventura Ignacio, Legidos-García María Ester, Tomás-Aguirre Francisco, Tejeda-Adell Manuel, Martínez-Peris Miriam, Marí-Beltrán Belén, Murillo-Llorente María Teresa
SONEV Research Group, School of Medicine and Health Sciences, Catholic University of Valencia San Vicente Mártir, C/Quevedo nº 2, 46001 Valencia, Spain.
Department of Nutrition. School of Medicine and Health Sciences, Catholic University of Valencia San Vicente Mártir, C/Quevedo nº 2, 46001 Valencia, Spain.
Biomedicines. 2024 Nov 24;12(12):2677. doi: 10.3390/biomedicines12122677.
Endocrine disruptors are substances capable of altering the functions of the endocrine system. There is evidence that some pesticides can be endocrine disruptors and, among some of their effects, we find alterations in pubertal development and in the function of the thyroid gland, which could be related to a greater tendency of obesity. The aim was to evaluate the evidence from clinical and preclinical studies on the association between pesticides used in agriculture and found in plant-based foods with overweight/obesity. This is a systematic review of articles on the impact of the use of endocrine disrupting pesticides on obesity, conducted according to the PRISMA-2020 guidelines. There was evidence that some pesticides, such as chlorpyrifos, pyrethroids, and neonicotinoids, may promote obesity and other anthropometric changes by altering lipid and glucose metabolism, modifying genes, or altering hormone levels such as leptin. Other studies suggest that perinatal exposure to chlorpyrifos or pesticides such as vinclozolin may alter lipid metabolism and promote weight gain in adulthood, whereas other pesticides such as boscalib, captan, thiacloprid, and ziram were not associated with changes in weight. Exposure to pesticides such as vinclozolin may be associated with a higher prevalence of overweight/obesity in later generations. The few studies that do not show these associations have methodological limitations in data collection with confounding variables. Further studies are needed to provide more and higher quality evidence to determine the true effect of these substances on obesity.
内分泌干扰物是能够改变内分泌系统功能的物质。有证据表明，一些农药可能是内分泌干扰物，在它们的一些影响中，我们发现青春期发育和甲状腺功能发生改变，这可能与肥胖倾向增加有关。目的是评估临床和临床前研究中关于农业中使用的、存在于植物性食物中的农药与超重/肥胖之间关联的证据。这是一项根据PRISMA - 2020指南对使用内分泌干扰性农药对肥胖影响的文章进行的系统综述。有证据表明，一些农药，如毒死蜱、拟除虫菊酯和新烟碱类农药，可能通过改变脂质和葡萄糖代谢、修饰基因或改变瘦素等激素水平来促进肥胖和其他人体测量学变化。其他研究表明，围产期接触毒死蜱或如乙烯菌核利等农药可能会改变脂质代谢并促进成年期体重增加，而其他农药如波司菌素、克菌丹、噻虫啉和福美锌与体重变化无关。接触如乙烯菌核利等农药可能与后代中超重/肥胖的较高患病率有关。少数未显示这些关联的研究在数据收集方面存在方法学局限性，存在混杂变量。需要进一步研究以提供更多更高质量的证据来确定这些物质对肥胖的真正影响。
