精神分裂症患者甘油三酯、残留胆固醇与全身炎症之间的不一致性
Discordance Between Triglycerides, Remnant Cholesterol and Systemic Inflammation in Patients with Schizophrenia.
作者信息
Wang Jeffrey, Kockx Maaike, Pennings Gabrielle J, Lambert Tim, Chow Vincent, Kritharides Leonard
机构信息
Atherosclerosis and Vascular Biology Laboratory, The ANZAC Research Institute, Concord Repatriation General Hospital, University of Sydney, Concord 2138, Australia.
Concord Clinical School, Faculty of Medicine and Health, University of Sydney, Camperdown 2050, Australia.
出版信息
Biomedicines. 2024 Dec 18;12(12):2884. doi: 10.3390/biomedicines12122884.
BACKGROUND/OBJECTIVES: Hypertriglyceridaemia and systemic inflammation are prevalent in patients with schizophrenia and contribute to an increased risk of cardiovascular disease. Although elevated triglycerides (TGs) and remnant cholesterol are linked to inflammation in the general population and individuals with metabolic syndrome, whether they are associated in patients with schizophrenia remains unclear.
METHODS
Fasting levels of TG, cholesterol (total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and remnant cholesterol)), and markers of systemic inflammation including high-sensitivity C-reactive protein (hsCRP), leukocyte counts and their differentials (neutrophils, monocytes and lymphocytes) were determined in 147 patients diagnosed with schizophrenia on long-term antipsychotic regimens and compared with 56 age- and sex-matched healthy controls. Apolipoprotein B and glycosylation of acute phase reactant (GlycA) signatures were assessed by NMR. Circulating cytokine levels were measured by a cytokine/chemokine multiplex assay.
RESULTS
Patients with schizophrenia had markedly elevated TG and remnant cholesterol relative to controls and had evidence of systemic inflammation with increased circulating hsCRP, GlycA, leukocyte, neutrophil counts and neutrophil-to-lymphocyte ratio (NLR). Unexpectedly TG and remnant cholesterol did not correlate with systemic inflammatory markers in patients with schizophrenia, and differences in inflammatory markers between controls and patients persisted after adjusting for the lipid profile. Interleukin (IL)-10 levels were increased in patients with schizophrenia, suggesting an anti-inflammatory signature.
CONCLUSIONS
The discordance between TG, remnant cholesterol and systemic inflammation in patients with schizophrenia suggests these are likely independent contributors to cardiovascular risk in this population.
背景/目的：高甘油三酯血症和全身炎症在精神分裂症患者中普遍存在，并导致心血管疾病风险增加。尽管在一般人群和患有代谢综合征的个体中，甘油三酯（TG）升高和残余胆固醇与炎症有关，但在精神分裂症患者中它们是否相关仍不清楚。
方法
测定了147例长期接受抗精神病药物治疗的精神分裂症患者的空腹TG、胆固醇（总胆固醇（TC）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）和残余胆固醇）水平，以及全身炎症标志物，包括高敏C反应蛋白（hsCRP）、白细胞计数及其分类（中性粒细胞、单核细胞和淋巴细胞），并与56名年龄和性别匹配的健康对照者进行比较。通过核磁共振评估载脂蛋白B和急性期反应物糖基化（GlycA）特征。通过细胞因子/趋化因子多重检测法测量循环细胞因子水平。
结果
与对照组相比，精神分裂症患者的TG和残余胆固醇显著升高，并有全身炎症的证据，表现为循环hsCRP、GlycA、白细胞、中性粒细胞计数和中性粒细胞与淋巴细胞比值（NLR）增加。出乎意料的是，精神分裂症患者的TG和残余胆固醇与全身炎症标志物不相关，在调整血脂谱后，对照组和患者之间的炎症标志物差异仍然存在。精神分裂症患者的白细胞介素（IL）-10水平升高，提示存在抗炎特征。
结论
精神分裂症患者中TG、残余胆固醇与全身炎症之间的不一致表明，这些可能是该人群心血管风险的独立因素。
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