Ottosson U B, Johansson B G, von Schoultz B
Am J Obstet Gynecol. 1985 Mar 15;151(6):746-50. doi: 10.1016/0002-9378(85)90509-5.
Subfractions of high-density lipoprotein cholesterol and its apolipoproteins were followed up in 58 postmenopausal women during three cycles of unopposed estrogen replacement therapy with 2 mg of estradiol valerate daily. During the last 10 days of the following three cycles the women received sequential addition of either 250 micrograms of levonorgestrel, 10 mg of medroxyprogesterone acetate, or 200 mg of natural micronized progesterone. Both progestogens significantly decreased total high-density lipoprotein cholesterol as well as subfraction 2 of high-density lipoprotein. Data suggest that doses and relative biologic activity of 19-norsteroids and 17-hydroxyprogesterone derivatives are more important for their metabolic effects than are qualitative differences. Natural progesterone had no apparent influence on high-density lipoprotein cholesterol or its subfractions and may develop into an attractive alternative to synthetic progestogens.
对58名绝经后女性在三个周期的每日2毫克戊酸雌二醇无对抗雌激素替代疗法期间，对高密度脂蛋白胆固醇及其载脂蛋白的亚组分进行了随访。在接下来三个周期的最后10天，这些女性依次添加了250微克左炔诺孕酮、10毫克醋酸甲羟孕酮或200毫克天然微粉化孕酮。两种孕激素均显著降低了总高密度脂蛋白胆固醇以及高密度脂蛋白亚组分2。数据表明，19-去甲甾体和17-羟孕酮衍生物的剂量和相对生物活性对其代谢作用比质量差异更重要。天然孕酮对高密度脂蛋白胆固醇及其亚组分没有明显影响，可能会成为合成孕激素的有吸引力的替代品。
