体外膜肺氧合用于新生儿呼吸衰竭的生命支持：一项单中心队列研究及系统评价

Extracorporeal Membrane Oxygenation as Life Support in Neonatal Respiratory Failure: A Single-Center Cohort Study and a Systematic Review.

作者信息

Falsaperla Raffaele, Zanai Rosanna, Collotta Ausilia Desiree, Sortino Vincenzo, Vitaliti Giovanna, Cimino Carla, Scalia Bruna, Vaccalluzzo Marco Simone, Spatuzza Michela, Privitera Grete Francesca, Pulvirenti Alfredo, Pavone Piero, Ruggieri Martino, Marino Andrea, Agati Salvatore

机构信息

Neonatal Intensive Care Unit, Azienda Ospedaliero Universitaria Policlinico "G. Rodolico-San Marco", San Marco Hospital, University of Catania, 95121 Catania, Italy.

Cardiovascular Department, Mediterranean Pediatric Cardiology Center, Bambino Gesù Children's Hospital, 98035 Taormina, Italy.

出版信息

Children (Basel). 2024 Nov 26;11(12):1441. doi: 10.3390/children11121441.

DOI:10.3390/children11121441

PMID:39767870

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11674827/

Abstract

BACKGROUND

Extracorporeal membrane oxygenation (ECMO) is a life support in newborns with severe respiratory failure. Our main objective was to evaluate the mortality of patients and define positive and negative predictive factors of survival.

METHODS

We performed a Strengthening the Reporting of Observational Studies in Epidemiology (STROBE)-conformed retrospective observational study and a systematic review, according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Our data were analyzed using R (v.4.2.1). We performed survival analysis, correlation analysis, and Fisher's exact test. The first endpoint was the mortality rate. The second endpoint was to evaluate all factors associated with survival. The third endpoint was focused on complications of ECMO.

RESULTS

Our study included 8 patients treated in our centers and 45 patients from the literature review. Survival was 79%. Positive predictive factors of survival were a length of ECMO of less than 10 days and male neonates, while prematurity and the presence of 2 complications were negative predictive factors.

CONCLUSIONS

ECMO functions as life support, although mortality and morbidity risks are high.

摘要

背景

体外膜肺氧合（ECMO）是严重呼吸衰竭新生儿的一种生命支持手段。我们的主要目的是评估患者的死亡率，并确定生存的阳性和阴性预测因素。

方法

我们按照流行病学观察性研究报告强化（STROBE）规范进行了一项回顾性观察性研究，并根据系统评价和Meta分析的首选报告项目（PRISMA）进行了系统评价。我们使用R（v.4.2.1）分析数据。我们进行了生存分析、相关性分析和Fisher精确检验。第一个终点是死亡率。第二个终点是评估与生存相关的所有因素。第三个终点聚焦于ECMO的并发症。