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矮小儿童维生素D水平与发育状况的关联

Association Between Vitamin D Levels and Developmental Status in Short-Stature Children.

作者信息

Dewi Mia Milanti, Imron Akhmad, Risan Nelly Amalia, Purnami Grace Mediana, Judistiani Raden Tina Dewi, Setiabudiawan Budi

机构信息

Departement of Child Health, Faculty of Medicine, Universitas Padjadjaran, Bandung 40161, Indonesia.

Department of Neurosurgery, Faculty of Medicine, Universitas Padjadjaran, Bandung 40161, Indonesia.

出版信息

Children (Basel). 2024 Dec 19;11(12):1542. doi: 10.3390/children11121542.

Abstract

The first two years of life are crucial for child growth and development, and short stature is a common issue influenced by nutritional deficiencies. This study aimed to determine the relationship between vitamin D levels and short stature in children under 2 years of age in Bandung. Conducted as part of the ALG Grant research entitled '', this case-control study included 221 children, of whom 46.1% were below average height. Nutritional status played a significant role, with short stature being associated with underweight (21.6%), severely underweight (29.4%), wasted (12.7%), and severely wasted (10.8%) conditions. However, the analysis revealed no significant difference in vitamin D levels between children with short stature and those with normal stature (median 28.8 vs. 28.8, = 0.555). Logistic regression showed that short stature increased the risk of developmental deviations by 5.46 times compared to normal stature. While short stature remains a concern in Bandung, vitamin D levels do not appear to influence the incidence of short stature or developmental deviations in this population.

摘要

生命的头两年对儿童的生长发育至关重要,身材矮小是受营养缺乏影响的常见问题。本研究旨在确定万隆2岁以下儿童维生素D水平与身材矮小之间的关系。作为名为“”的ALG资助研究的一部分进行的这项病例对照研究纳入了221名儿童,其中46.1%的儿童身高低于平均水平。营养状况起着重要作用,身材矮小与体重不足(21.6%)、严重体重不足(29.4%)、消瘦(12.7%)和严重消瘦(10.8%)状况相关。然而,分析显示身材矮小的儿童与身材正常的儿童之间维生素D水平无显著差异(中位数28.8对28.8,P = 0.555)。逻辑回归显示,与正常身材相比,身材矮小使发育偏差风险增加5.46倍。虽然身材矮小在万隆仍然是一个令人担忧的问题,但维生素D水平似乎并未影响该人群中身材矮小或发育偏差的发生率。

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