Naskar Atanu, Kilari Sreenivasulu, Baranwal Gaurav, Kane Jamie, Misra Sanjay
Vascular and Interventional Radiology Translational Laboratory, Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Bioengineering (Basel). 2024 Dec 3;11(12):1222. doi: 10.3390/bioengineering11121222.
Nanoparticle (NP)-based drug delivery systems have received widespread attention due to the excellent physicochemical properties of nanomaterials. Different types of NPs such as lipid NPs, poly(lactic-co-glycolic) acid (PLGA) NPs, inorganic NPs (e.g., iron oxide and Au), carbon NPs (graphene and carbon nanodots), 2D nanomaterials, and biomimetic NPs have found favor as drug delivery vehicles. In this review, we discuss the different types of customized NPs for intravascular drug delivery, nanoparticle behaviors (margination, adhesion, and endothelium uptake) in blood vessels, and nanomaterial compatibility for successful drug delivery. Additionally, cell surface protein targets play an important role in targeted drug delivery, and various vascular drug delivery studies using nanoparticles conjugated to these proteins are reviewed. Finally, limitations, challenges, and potential solutions for translational research regarding NP-based vascular drug delivery are discussed.
基于纳米颗粒（NP）的药物递送系统因纳米材料优异的物理化学性质而受到广泛关注。不同类型的纳米颗粒，如脂质纳米颗粒、聚乳酸-羟基乙酸共聚物（PLGA）纳米颗粒、无机纳米颗粒（如氧化铁和金）、碳纳米颗粒（石墨烯和碳纳米点）、二维纳米材料和仿生纳米颗粒，已成为备受青睐的药物递送载体。在本综述中，我们讨论了用于血管内药物递送的不同类型定制纳米颗粒、纳米颗粒在血管中的行为（边缘化、黏附及内皮摄取）以及实现成功药物递送所需的纳米材料兼容性。此外，细胞表面蛋白靶点在靶向药物递送中发挥着重要作用，本文还综述了使用与这些蛋白偶联的纳米颗粒进行的各种血管药物递送研究。最后，讨论了基于纳米颗粒的血管药物递送转化研究的局限性、挑战及潜在解决方案。
