Martínez-Espinosa Israel, Serrato José A, Cabello-Gutiérrez Carlos, Carlos-Reyes Ángeles, Ortiz-Quintero Blanca
Department of Molecular Biomedicine and Translational Research, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico.
Department of Research in Virology and Mycology, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, Mexico.
Life (Basel). 2024 Dec 4;14(12):1608. doi: 10.3390/life14121608.
Exosome-derived microRNAs (miRNAs) are potential biomarkers for lung cancer detection and monitoring through liquid biopsy. These small, non-coding RNA molecules are found within exosomes, which are extracellular vesicles released from cells. Their stability in biofluids, such as blood, positions them as candidates for minimally invasive diagnostics. Multiple studies have shown that lung cancer patients exhibit distinct miRNA profiles compared to healthy individuals. This finding suggests that exosome-derived miRNAs could serve as valuable biomarkers for diagnosis, prognosis, and evaluating therapeutic responses. This review summarizes recent research on exosome-derived miRNAs in liquid biopsies, including blood, pleural effusion, and pleural lavage, as biomarkers for lung cancer, focusing on publications from the last five years.
外泌体衍生的微小RNA（miRNA）是通过液体活检进行肺癌检测和监测的潜在生物标志物。这些小的非编码RNA分子存在于外泌体中，外泌体是细胞释放的细胞外囊泡。它们在生物流体（如血液）中的稳定性使其成为微创诊断的候选物。多项研究表明，与健康个体相比，肺癌患者表现出不同的miRNA谱。这一发现表明，外泌体衍生的miRNA可作为诊断、预后和评估治疗反应的有价值生物标志物。本综述总结了最近关于液体活检（包括血液、胸腔积液和胸腔灌洗）中外泌体衍生miRNA作为肺癌生物标志物的研究，重点关注过去五年的出版物。
