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小儿阻塞性睡眠呼吸暂停的手术治疗:疗效、结局及替代方案——一项系统评价

Surgical Management of Pediatric Obstructive Sleep Apnea: Efficacy, Outcomes, and Alternatives-A Systematic Review.

作者信息

Dipalma Gianna, Inchingolo Angelo Michele, Palumbo Irene, Guglielmo Mariafrancesca, Riccaldo Lilla, Morolla Roberta, Inchingolo Francesco, Palermo Andrea, Charitos Ioannis Alexandros, Inchingolo Alessio Danilo

机构信息

Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70121 Bari, Italy.

Department of Experimental Medicine, University of Salento, 73100 Lecce, Italy.

出版信息

Life (Basel). 2024 Dec 12;14(12):1652. doi: 10.3390/life14121652.

Abstract

AIM

Obstructive sleep apnea (OSA) is the most prevalent sleep-related breathing disorder. OSA affects approximately 2 million Italians, although only 3% receive a diagnosis and correct treatment. This review aims to provide an overview to guide clinical decision making, ensuring that patients receive the most appropriate treatment for their specific condition.

MATERIAL AND METHODS

This systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and registered at PROSPERO under the ID CRD42024593760. A search on PubMed, Scopus, and Web of Science was performed to find papers that matched the topic, using the following Boolean keywords: ("obstructive sleep apnea" OR "OSA" OR "sleep apnea, obstructive") AND ("surgery" OR "surgical" OR "surgical techniques" OR "surgical treatment" OR "operative" OR "surgical procedures") AND ("treatment" OR "therapy" OR "management").

RESULT

The electronic database search found 20337 publications. After the screening and eligibility phase, 15 papers were chosen for the qualitative analysis.

CONCLUSIONS

Adenotonsillectomy (AT) significantly improves secondary outcomes like behavioral issues and quality of life, compared to watchful waiting with supportive care (WWSC). Alternative approaches such as tonsillotomy and adenopharyngoplasty (APP) offer promising results, with less postoperative discomfort and lower complication rates. However, further large-scale studies are needed to refine surgical techniques, assess long-term outcomes, and optimize individualized treatment strategies for OSA.

摘要

目的

阻塞性睡眠呼吸暂停(OSA)是最常见的与睡眠相关的呼吸障碍。OSA影响约200万意大利人,尽管只有3%的人得到诊断和正确治疗。本综述旨在提供一个概述以指导临床决策,确保患者针对其特定病情接受最合适的治疗。

材料与方法

本系统综述按照系统评价和Meta分析的首选报告项目(PRISMA)指南进行,并在国际前瞻性注册系统(PROSPERO)上注册,注册号为CRD42024593760。在PubMed、Scopus和科学网(Web of Science)上进行检索,以查找与该主题匹配的论文,使用以下布尔关键词:(“阻塞性睡眠呼吸暂停”或“OSA”或“睡眠呼吸暂停,阻塞性”)与(“手术”或“外科的”或“手术技术”或“手术治疗”或“手术的”或“手术程序”)与(“治疗”或“疗法”或“管理”)。

结果

电子数据库检索找到20337篇出版物。在筛选和资格评估阶段后,选择了15篇论文进行定性分析。

结论

与支持性护理下的观察等待(WWSC)相比,腺样体扁桃体切除术(AT)显著改善了行为问题和生活质量等次要结局。扁桃体切开术和腺样体咽成形术(APP)等替代方法显示出有前景的结果,术后不适较少且并发症发生率较低。然而,需要进一步的大规模研究来完善手术技术、评估长期结局并优化OSA的个体化治疗策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0a73/11677306/e6ce1112d5e5/life-14-01652-g001.jpg

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