慢性阻塞性肺疾病与阻塞性睡眠呼吸暂停重叠综合征：流行病学、病理生理学和治疗的最新进展。
Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnea Overlap Syndrome: An Update on the Epidemiology, Pathophysiology, and Management.
机构信息
Department of Thoracic Medicine, Level 4 Xavier Building, St Vincent's Hospital, 390 Victoria Street, Darlinghurst, NSW 2010, Australia; Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Level 11 Royal Prince Alfred Hospital, Missenden Road, Camperdown, NSW 2050, Australia; Faculty of Medicine and Health, Sydney Medical School, Sydney Medical School Central Sydney, The University of Sydney, NSW 2006, Australia; The Woolcock Institute of Medical Research, Macquarie University, 2 Innovation Road, Macquarie Park, NSW 2113, Australia.
Lane Fox Respiratory Service, Division of Heart, Lung and Critical Care, Guy's & St Thomas NHS Foundation Trust, Ground Floor, South Wing, St Thomas' Hospital, Westminster Bridge Road, London SE1 7EH; King's College London, Strand, London WC2R 2LS, United Kingdon.
出版信息
Sleep Med Clin. 2024 Sep;19(3):405-417. doi: 10.1016/j.jsmc.2024.04.003. Epub 2024 May 28.
This review provides an up-to-date summary of the prevalence, pathophysiology, diagnosis, and treatment of the chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) overlap syndrome (OVS). The presence of OVS is high in patients with COPD and in patients with OSA and is associated with profound nocturnal oxygen desaturation and systemic inflammation. There is a high prevalence of cardiovascular disease among patients with OVS and this likely contributes to increased mortality. Observational studies suggest that positive airway pressure therapy improves survival and reduces COPD exacerbations; however, randomized controlled trials will be required to confirm these findings.
本综述提供了慢性阻塞性肺疾病（COPD）和阻塞性睡眠呼吸暂停（OSA）重叠综合征（OVS）的患病率、病理生理学、诊断和治疗的最新总结。在 COPD 患者以及 OSA 患者中，OVS 的发生率很高，与严重的夜间氧饱和度下降和全身炎症有关。OVS 患者中心血管疾病的患病率很高，这可能导致死亡率增加。观察性研究表明，气道正压治疗可改善生存率并减少 COPD 恶化；然而，需要随机对照试验来证实这些发现。
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