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优化围手术期护理方案在小儿神经肌肉型脊柱侧弯手术中的可行性及效果的前瞻性研究

A Prospective Study on the Feasibility and Effect of an Optimized Perioperative Care Protocol in Pediatric Neuromuscular Scoliosis Surgery.

作者信息

Naume Marie Mostue, Hoei-Hansen Christina Engel, Born Alfred Peter, Brekke Ghita, Høj Astrid, Nielsen Maja Risager, Borgwardt Lise, Vissing John, Dirks Jesper, Rye Anne Kathrine Stæhr, Møller Morten Hylander, Andersen Thomas Borbjerg, Ørngreen Mette Cathrine

机构信息

Department of Pediatric and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark.

Copenhagen Neuromuscular Center, Department of Neurology, Copenhagen University Hospital, Rigshospitalet, 2100 Copenhagen, Denmark.

出版信息

J Clin Med. 2024 Dec 23;13(24):7848. doi: 10.3390/jcm13247848.

Abstract

: A recent retrospective study conducted by our team identified a high percentage of postoperative pneumonia in children with neuromuscular scoliosis. Based on the findings in that study and our clinical experience, we aimed to assess the effectiveness of an optimized perioperative care protocol. : As part of a prospective study, a multidisciplinary team developed a protocol that included preoperative nutritional and respiratory optimization, intra- and postoperative intravenous glucose infusion, early extubation, and postoperative nutritional optimization. Non-ambulant children between 6 and 18 years of age with neuromuscular scoliosis were eligible for inclusion in the study. The primary outcome was the rate of postoperative pneumonia within 30 days of surgery. The secondary outcome measures were the rate of postoperative complications, including readmissions. All the outcomes were compared to a retrospective control group that was receiving standard care during the same period. : Eleven children were included in the intervention group and 14 in the control group. In regard to the intervention group, the nutritional and respiratory assessment before surgery resulted in optimized treatment in 8/11 patients (73%) and 9/11 patients (82%), respectively. One patient (9%) in the intervention group and three patients (21%) in the control group developed postoperative pneumonia (relative risk 0.42, 95% confidence interval 0.05-3.50). The intervention and control groups did not differ significantly in terms of postoperative complications or readmission rates. : The multidisciplinary care protocol is feasible, with a high compliance rate in regard to study procedures. A numerical reduction in the 30-day pneumonia rate did occur in the intervention group; however, this reduction did not reach statistical significance.

摘要

我们团队最近进行的一项回顾性研究发现,神经肌肉型脊柱侧弯患儿术后肺炎的发生率很高。基于该研究结果和我们的临床经验,我们旨在评估优化围手术期护理方案的有效性。

作为一项前瞻性研究的一部分,一个多学科团队制定了一项方案,其中包括术前营养和呼吸功能优化、术中和术后静脉输注葡萄糖、早期拔管以及术后营养优化。6至18岁不能行走的神经肌肉型脊柱侧弯患儿符合纳入该研究的条件。主要结局是术后30天内的肺炎发生率。次要结局指标是术后并发症发生率,包括再次入院率。所有结局均与同期接受标准护理的回顾性对照组进行比较。

干预组纳入了11名儿童,对照组纳入了14名儿童。关于干预组,术前营养和呼吸评估分别使8/11例患者(73%)和9/11例患者(82%)得到了优化治疗。干预组有1例患者(9%)发生术后肺炎,对照组有3例患者(21%)发生术后肺炎(相对危险度0.42,95%置信区间0.05 - 3.50)。干预组和对照组在术后并发症或再次入院率方面无显著差异。

多学科护理方案是可行的,研究程序的依从率很高。干预组30天肺炎发生率确实有数值上的降低;然而,这种降低未达到统计学显著性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fc9f/11676504/2bf49906d6f4/jcm-13-07848-g001.jpg

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