Rusciano Dario
Fidia Ophthalmics, 95124 Catania, Italy.
Medicina (Kaunas). 2024 Nov 27;60(12):1957. doi: 10.3390/medicina60121957.
This review highlights the therapeutic potential of epigallocatechin gallate (EGCG) and forskolin in managing retinal diseases, with a focus on glaucoma, age-related macular degeneration (AMD), and diabetic retinopathy. EGCG, a potent polyphenol from green tea, exhibits significant antioxidant, anti-inflammatory, and neuroprotective effects, making it a promising candidate for reducing oxidative stress and inflammation in ocular tissues. Forskolin, a diterpene from Coleus forskohlii, increases cyclic AMP (cAMP) levels, which helps lower intraocular pressure (IOP) and provides neuroprotection. Both compounds target critical pathways involved in retinal disease progression, including oxidative stress, mitochondrial dysfunction, and inflammation, offering complementary therapeutic benefits. This review consolidates preclinical and clinical studies, highlighting the potential of EGCG and forskolin as adjunctive or alternative treatments for retinal diseases. Future research should explore the synergistic effects of these compounds, particularly in combination therapies aimed at addressing multiple pathogenic mechanisms in retinal health.
本综述重点介绍了表没食子儿没食子酸酯（EGCG）和毛喉素在治疗视网膜疾病方面的潜力，重点关注青光眼、年龄相关性黄斑变性（AMD）和糖尿病性视网膜病变。EGCG是一种来自绿茶的强效多酚，具有显著的抗氧化、抗炎和神经保护作用，使其成为减轻眼组织氧化应激和炎症的有前景的候选药物。毛喉素是一种来自毛喉鞘蕊花的二萜类化合物，可提高环磷酸腺苷（cAMP）水平，有助于降低眼压（IOP）并提供神经保护。这两种化合物均针对视网膜疾病进展所涉及的关键途径，包括氧化应激、线粒体功能障碍和炎症，具有互补的治疗益处。本综述整合了临床前和临床研究，强调了EGCG和毛喉素作为视网膜疾病辅助或替代治疗方法的潜力。未来的研究应探索这些化合物的协同作用，特别是在旨在解决视网膜健康中多种致病机制的联合疗法中。
