Lee Hewang, Feranil Jun B, Jose Pedro A
Department of Medicine, The George Washington University School of Medicine & Health Sciences, Washington, DC 20052, USA.
Department of Pharmacology & Physiology, The George Washington University School of Medicine & Health Sciences, Washington, DC 20052, USA.
Int J Mol Sci. 2024 Dec 11;25(24):13284. doi: 10.3390/ijms252413284.
Neuropeptide FF (NPFF) is an endogenous octapeptide that was originally isolated from the bovine brain. It belongs to the RFamide family of peptides that has a wide range of physiological functions and pathophysiological effects. NPFF and its receptors, NPFFR1 and NPFFR2, abundantly expressed in rodent and human brains, participate in cardiovascular regulation. However, the expressions of NPFF and its receptors are not restricted within the central nervous system but are also found in peripheral organs, including the kidneys. Both NPFFR1 and NPFFR2 mainly couple to Gαi/o, which inhibits cyclic adenosine monophosphate (cAMP) production. NPFF also weakly binds to other RFamide receptors and the Mas receptor. Relevant published articles were searched in PubMed, Google Scholar, Web of Science, and Scopus. Herein, we review evidence for the role of NPFF in the regulation of blood pressure, in the central nervous system, particularly within the hypothalamic paraventricular nucleus and the brainstem, and the kidneys. NPFF is a potential target in the treatment of hypertension.
神经肽FF（NPFF）是一种内源性八肽，最初从牛脑中分离出来。它属于具有广泛生理功能和病理生理作用的RFamide肽家族。NPFF及其受体NPFFR1和NPFFR2在啮齿动物和人类大脑中大量表达，参与心血管调节。然而，NPFF及其受体的表达并不局限于中枢神经系统，在外周器官包括肾脏中也有发现。NPFFR1和NPFFR2都主要与Gαi/o偶联，抑制环磷酸腺苷（cAMP）的产生。NPFF也与其他RFamide受体和Mas受体弱结合。在PubMed、谷歌学术、科学网和Scopus上搜索了相关已发表文章。在此，我们综述了NPFF在血压调节中的作用证据，涉及中枢神经系统，特别是下丘脑室旁核和脑干，以及肾脏。NPFF是高血压治疗的一个潜在靶点。
