Popovic V, Popovic P
Am J Physiol. 1985 Mar;248(3 Pt 2):R308-11. doi: 10.1152/ajpregu.1985.248.3.R308.
Adult mongrel dogs were rapidly cooled to a body temperature of 4-5 degrees C with a combination of internal (core) cooling and external surface cooling. All dogs survived profound cooling and 2-h circulatory arrest when profound hemodilution and drainage of the left ventricle were used during cooling and when preferential microwave chest rewarming and hypervolemia were employed during rewarming. After recovery no permanent neurological damage was observed. The histology of the brain and heart of animals killed 6 mo after the cooling indicated normal tissue. When during rewarming the selective microwave chest heating was not used, fewer dogs survived the 2-h circulatory arrest.
成年杂种犬通过内部（核心）冷却和体表冷却相结合的方式迅速冷却至体温4-5摄氏度。在冷却过程中采用深度血液稀释和左心室引流，以及在复温过程中采用优先的微波胸部复温和高血容量时，所有犬只在深度冷却和2小时循环停止后均存活。恢复后未观察到永久性神经损伤。冷却6个月后处死的动物的脑和心脏组织学显示组织正常。在复温过程中未使用选择性微波胸部加热时，存活2小时循环停止的犬只较少。
