Zhu Keyu, Cai Yuang, Lan Lan, Luo Na
School of Medicine, Nankai University, Tianjin 300071, China.
School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, China.
Int J Mol Sci. 2024 Dec 14;25(24):13413. doi: 10.3390/ijms252413413.
Ferroptosis, a novel form of cell death discovered in recent years, is typically accompanied by significant iron accumulation and lipid peroxidation during the process. This article systematically elucidates how tumor metabolic reprogramming affects the ferroptosis process in tumor cells. The paper outlines the basic concepts and physiological significance of tumor metabolic reprogramming and ferroptosis, and delves into the specific regulatory mechanisms of glucose metabolism, protein metabolism, and lipid metabolism on ferroptosis. We also explore how complex metabolic changes in the tumor microenvironment further influence the response of tumor cells to ferroptosis. Glucose metabolism modulates ferroptosis sensitivity by influencing intracellular energetic status and redox balance; protein metabolism, involving amino acid metabolism and protein synthesis, plays a crucial role in the initiation and progression of ferroptosis; and the relationship between lipid metabolism and ferroptosis primarily manifests in the generation and elimination of lipid peroxides. This review aims to provide a new perspective on how tumor cells regulate ferroptosis through metabolic reprogramming, with the ultimate goal of offering a theoretical basis for developing novel therapeutic strategies targeting tumor metabolism and ferroptosis.
铁死亡是近年来发现的一种新型细胞死亡形式，在此过程中通常伴随着大量铁积累和脂质过氧化。本文系统阐述了肿瘤代谢重编程如何影响肿瘤细胞中的铁死亡过程。该论文概述了肿瘤代谢重编程和铁死亡的基本概念及生理意义，并深入探讨了糖代谢、蛋白质代谢和脂质代谢对铁死亡的具体调控机制。我们还探讨了肿瘤微环境中的复杂代谢变化如何进一步影响肿瘤细胞对铁死亡的反应。糖代谢通过影响细胞内能量状态和氧化还原平衡来调节铁死亡敏感性；蛋白质代谢，包括氨基酸代谢和蛋白质合成，在铁死亡的起始和进展中起关键作用；脂质代谢与铁死亡的关系主要体现在脂质过氧化物的产生和消除上。本综述旨在为肿瘤细胞如何通过代谢重编程调节铁死亡提供新视角，最终目的是为开发针对肿瘤代谢和铁死亡的新型治疗策略提供理论依据。
