Alotaibi Mshari A, Alharthi Abdulrahman I, F Qahtan Talal, Bakht Md Afroz
Department of Chemistry, College of Science and Humanities in Al-Kharj, Prince Sattam Bin Abdulaziz University, P.O. Box 173, Al-Kharj 11942, Saudi Arabia.
Department of Physics, College of Science and Humanities in Al-Kharj, Prince Sattam Bin Abdulaziz University, P.O. Box 173, Al-Kharj 11942, Saudi Arabia.
Materials (Basel). 2024 Dec 20;17(24):6235. doi: 10.3390/ma17246235.
This study explores a sustainable method for synthesizing quinazoline derivatives through visible light-driven photocatalysis using curcumin-sensitized titanium dioxide (TiO) nanoparticles. A one-pot, three-component reaction involving aldehydes, urea/thiourea, and dimedone was utilized to efficiently produce quinazoline compounds. The photocatalytic performance of curcumin-sensitized TiO (Cur-TiO) was compared to pure TiO (P-TiO), with Cur-TiO showing significantly enhanced activity. Under optimized conditions-light intensity of 100 mW/cm, catalyst concentration of 1 mg/mL, and a reaction time of 40 min-a 97% product yield was achieved. The Cur-TiO catalyst demonstrated excellent reusability, maintaining high efficiency over four consecutive cycles with minimal performance loss. This work underscores the potential of natural dye sensitization to extend light absorption of TiO into the visible spectrum, providing an eco-friendly and cost-effective approach to sustainable organic synthesis.
本研究探索了一种可持续的方法，通过使用姜黄素敏化的二氧化钛（TiO₂）纳米颗粒进行可见光驱动的光催化来合成喹唑啉衍生物。利用醛、尿素/硫脲和达米酮的一锅三组分反应高效制备喹唑啉化合物。将姜黄素敏化的TiO₂（Cur-TiO₂）的光催化性能与纯TiO₂（P-TiO₂）进行了比较，结果表明Cur-TiO₂的活性显著增强。在优化条件下——光强为100 mW/cm²、催化剂浓度为1 mg/mL以及反应时间为40分钟——产物收率达到了97%。Cur-TiO₂催化剂表现出优异的可重复使用性，在连续四个循环中保持高效率，性能损失极小。这项工作强调了天然染料敏化将TiO₂的光吸收扩展到可见光谱的潜力，为可持续有机合成提供了一种环保且经济高效的方法。
