Hong Seeun, Park Juwon, Oh Yoojeong, Cho Hanhee, Kim Kwangmeyung
Graduate School of Pharmaceutical Sciences, College of Pharmacy, Ewha Womans University, Seoul 03760, Republic of Korea.
Molecules. 2024 Dec 11;29(24):5855. doi: 10.3390/molecules29245855.
Cancer immunotherapy using immune checkpoint blockades has emerged as a promising therapeutic approach. However, immunotherapy faces challenges such as low response rates in solid tumors, necessitating strategies to remodel the immune-suppressive tumor microenvironment (TME) into an immune-activated state. One of the primary approaches to achieve this transformation is through the induction of immunogenic cell death (ICD). Herein, we discussed strategies to maximize ICD induction using nanoparticles. In particular, this review highlighted various studies integrating chemotherapy, radiation therapy (RT), photodynamic therapy (PDT), and photothermal therapy (PTT) with nanoparticle-based immunotherapy. The research covered in this review aims to provide valuable insights for future studies on nanoparticle-assisted immunotherapy.
使用免疫检查点阻断剂的癌症免疫疗法已成为一种有前景的治疗方法。然而，免疫疗法面临着诸如实体瘤中低反应率等挑战，因此需要将免疫抑制性肿瘤微环境（TME）重塑为免疫激活状态的策略。实现这种转变的主要方法之一是通过诱导免疫原性细胞死亡（ICD）。在此，我们讨论了使用纳米颗粒最大化ICD诱导的策略。特别是，本综述重点介绍了将化疗、放射治疗（RT）、光动力疗法（PDT）和光热疗法（PTT）与基于纳米颗粒的免疫疗法相结合的各种研究。本综述涵盖的研究旨在为未来关于纳米颗粒辅助免疫疗法的研究提供有价值的见解。
