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具有潜在生物活性的环状砜化合物合成的最新进展

Recent Advances in the Synthesis of Cyclic Sulfone Compounds with Potential Biological Activity.

作者信息

Huang Hong-Li, Shi Ya-Qian, Ning Jia-Xin, Li Shan, Song Dian-Tao, Gao Fei, Ma Na

机构信息

College of Chemistry and Chemical Engineering, Liaocheng University, Liaocheng 252059, China.

Shanghai Kinlita Chemical Co., Ltd., Shanghai 201417, China.

出版信息

Molecules. 2024 Dec 12;29(24):5868. doi: 10.3390/molecules29245868.

Abstract

In recent years, cyclic sulfone compounds, a subset of biologically active heterocyclic compounds, have gained considerable attention due to their potential in the development of novel active pharmaceutical ingredients. This review focuses on identifying simple, mild, environmentally friendly, and efficient synthesis methods. Various catalytic approaches for the synthesis of cyclic sulfone compounds are systematically reviewed, highlighting their advantages and potential applications in pharmaceutical development.

摘要

近年来,环状砜化合物作为生物活性杂环化合物的一个子集,因其在新型活性药物成分开发中的潜力而备受关注。本综述着重于确定简单、温和、环境友好且高效的合成方法。系统综述了合成环状砜化合物的各种催化方法,突出了它们在药物开发中的优势和潜在应用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/823d/11678439/a370e540f144/molecules-29-05868-g001.jpg

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