O'Duffy G, Chahl L A
Eur J Pharmacol. 1979 Aug 15;57(4):377-86. doi: 10.1016/0014-2999(79)90500-4.
The effect of intracutaneous adrenaline and noradrenaline (5 X 10(-12) and 5 X 10(-11) mol) was examined on the oedema (Evans blue dye leakage) response of rats to several inflammatory agents. The catecholamines reduced the oedema response to all agents tested except prostaglandin E1 (PGE1) which was significantly potentiated by noradrenaline (5 X 10(-11) mol), and a combination of bradykinin 5 X 10(-11) mol with PGE1 5 X 10(-10) mol which was not significantly affected by any dose of catecholamine. Adrenaline was more effective than noradrenaline in reducing oedema produced by 5-hydroxytryptamine (5HT) and histamine and by agents which release these amines (compound 48/80, dextran and antigen challenge with egg albumin in sensitized rats), but noradrenaline was more potent against bradykinin-induced oedema. The inhibitory effect of catecholamines against oedema produced by histamine and 5HT was abolished by a combination of phentolamine and propranolol. It was concluded that the oedema-inhibiting effect of catecholamines is due to alpha- and beta-adrenoreceptor mediated actions.
研究了皮内注射肾上腺素和去甲肾上腺素（5×10⁻¹²和5×10⁻¹¹摩尔）对大鼠对几种炎症介质的水肿（伊文思蓝染料渗漏）反应的影响。除前列腺素E1（PGE1）外，儿茶酚胺可降低对所有测试介质的水肿反应，去甲肾上腺素（5×10⁻¹¹摩尔）可显著增强PGE1的作用，而5×10⁻¹¹摩尔缓激肽与5×10⁻¹⁰摩尔PGE1的组合不受任何剂量儿茶酚胺的显著影响。在减轻5-羟色胺（5HT）和组胺以及释放这些胺类的介质（化合物48/80、右旋糖酐和致敏大鼠中用卵清蛋白进行抗原攻击）所产生的水肿方面，肾上腺素比去甲肾上腺素更有效，但去甲肾上腺素对缓激肽诱导的水肿更有效。酚妥拉明和普萘洛尔的组合消除了儿茶酚胺对组胺和5HT所产生水肿的抑制作用。得出的结论是，儿茶酚胺的水肿抑制作用是由α和β肾上腺素能受体介导的作用所致。
