Lee Jangho, Choi Hyo-Kyoung, Shin Hee Soon, Kim Gun-Dong
Division of Food Functionality Research, Korea Food Research Institute (KFRI), Wanju 55365, Republic of Korea.
Department of Food Biotechnology, Korea University of Science and Technology (UST), Daejeon 34113, Republic of Korea.
Molecules. 2024 Dec 17;29(24):5951. doi: 10.3390/molecules29245951.
Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by immune dysregulation, skin barrier dysfunction, and a significant patient burden. Recent studies have highlighted the aryl hydrocarbon receptor (AhR) as a promising therapeutic target for AD management because of its pivotal role in modulating immune responses and maintaining skin barrier integrity. The dysfunction of the AhR pathway has been linked to AD pathogenesis, emphasizing the need for therapies that can restore its regulatory functions. Natural products have emerged as potential modulators of the AhR and are effective and safe alternatives to conventional treatments. Compounds such as curcumin, resveratrol, quercetin, and microbial metabolites have demonstrated the ability to activate AhR, reduce inflammation, and promote skin barrier function. These natural agents have fewer side effects and enhance patient compliance compared with conventional therapies, making them attractive candidates for long-term AD management. The integration of natural products targeting the AhR pathway provides a multifaceted approach that alleviates symptoms, addresses underlying disease mechanisms, and promotes sustainable improvements in skin health. This review highlights the therapeutic potential of natural AhR modulators and their potential roles in enhancing patient outcomes through novel integrative treatment strategies.
特应性皮炎（AD）是一种慢性炎症性皮肤病，其特征为免疫失调、皮肤屏障功能障碍以及给患者带来沉重负担。最近的研究强调芳烃受体（AhR）作为AD治疗的一个有前景的靶点，因为它在调节免疫反应和维持皮肤屏障完整性方面起着关键作用。AhR信号通路功能障碍与AD发病机制相关，这凸显了对能够恢复其调节功能的疗法的需求。天然产物已成为AhR的潜在调节剂，并且是传统治疗的有效且安全的替代方案。姜黄素、白藜芦醇、槲皮素等化合物以及微生物代谢产物已证明具有激活AhR、减轻炎症和促进皮肤屏障功能的能力。与传统疗法相比，这些天然药物副作用更少，能提高患者的依从性，使其成为AD长期管理的有吸引力的候选药物。针对AhR信号通路的天然产物整合提供了一种多方面的方法，可缓解症状、解决潜在疾病机制并促进皮肤健康的可持续改善。本综述强调了天然AhR调节剂的治疗潜力及其通过新型综合治疗策略改善患者预后的潜在作用。
