Drevinskas Tomas, Maruška Audrius, Ihara Hirotaka, Takafuji Makoto, Jonušauskas Linas, Armonavičius Domantas, Stankevičius Mantas, Bimbiraitė-Survilienė Kristina, Skrzydlewska Elzbieta, Ragažinskienė Ona, Kuwahara Yutaka, Nagaoka Shoji, Kaškonienė Vilma, Kubilienė Loreta
Instrumental Analysis Open Access Centre, Faculty of Natural Sciences, Vytautas Magnus University, 44404 Kaunas, Lithuania.
Faculty of Advanced Science and Technology, Kumamoto University, Kumamoto 860-8555, Japan.
Micromachines (Basel). 2024 Nov 28;15(12):1430. doi: 10.3390/mi15121430.
This paper introduces a novel contactless single-chip detector that utilizes impedance-to-digital conversion technology to measure impedance in the microfluidic channel or capillary format analytical device. The detector is designed to operate similarly to capacitively coupled contactless conductivity detectors for capillary electrophoresis or chromatography but with the added capability of performing frequency sweeps up to 200 kHz. At each recorded data point, impedance and phase-shift data can be extracted, which can be used to generate impedance versus frequency plots, or phase-shift versus frequency plots. Real and imaginary parts can also be calculated from the data, allowing for the generation of Nyquist diagrams. This detector represents the first of its kind in the contactless conductivity class to provide spectrum-type data, as demonstrated in capillary electrophoresis experiments.
本文介绍了一种新型非接触式单芯片检测器，该检测器利用阻抗-数字转换技术来测量微流控通道或毛细管形式分析装置中的阻抗。该检测器的设计与用于毛细管电泳或色谱分析的电容耦合非接触式电导检测器类似，但增加了执行高达200 kHz频率扫描的能力。在每个记录的数据点，可以提取阻抗和相移数据，这些数据可用于生成阻抗与频率的关系图或相移与频率的关系图。也可以从数据中计算实部和虚部，从而生成奈奎斯特图。如毛细管电泳实验所示，该检测器是同类非接触式电导检测器中首个能够提供光谱类型数据的。
