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来自银纳米颗粒:对虫卵潜在杀卵活性的评估

Silver Nanoparticles from : Evaluation of Potential Ovicidal Activity on Eggs.

作者信息

Ferraz Carolina Magri, Comério Lara Coslop, Segantine Vinícius Bastos Salles, de Assis João Pedro Barbosa, Costa Silva Laryssa Pinheiro, Bezerra Lara De Nadai Rodrigues, de Araújo Jackson Victor, Vilela Vinícius Longo Ribeiro, Soares Filippe Elias de Freitas, Rossi Gabriel Augusto Marques, Tobias Fernando Luiz, Langoni Helio, Braga Fabio Ribeiro

机构信息

Laboratório de Parasitologia Experimental e Controle Biológico, Universidade Vila Velha, Rua São Joao, 48, Vila Velha 29101-420, ES, Brazil.

Departamento de Medicina Veterinária, Universidade Federal de Viçosa, Avenida PH Rolfs, Viçosa 36570-000, MG, Brazil.

出版信息

Pathogens. 2024 Nov 27;13(12):1043. doi: 10.3390/pathogens13121043.

Abstract

The filtrate of the nematophagous fungus produces silver nanoparticles (AgNPs) with nematicidal potential. However, there are currently no reports of its activity against eggs. The aim of this study was to investigate the potential ovicidal activity of AgNPs- on eggs. eggs were obtained from the dissection of the uterus of adult female nematodes. After the biosynthesis of AgNPs, two experimental assays (A and B) were performed. In assay A, the ovicidal activity of AgNPs on eggs was evaluated after 15 and 30 days of interaction. In assay B, the inhibition (development) of the eggs was measured after 30 days of interaction. The results of assay A showed that the AgNPs destroyed an average of 47% of the eggs tested by the end of the experiment, causing significant structural damage. In assay B, an inhibition rate of 88% was observed at the end of 30 days. The results of the ovicidal activity of AgNP- were promising and indicate the potential for future studies on these biomolecules with ovicidal properties.

摘要

食线虫真菌的滤液可产生具有杀线虫潜力的银纳米颗粒(AgNPs)。然而,目前尚无关于其对虫卵活性的报道。本研究的目的是探究AgNPs对虫卵的潜在杀卵活性。虫卵取自成年雌性线虫子宫的解剖。在AgNPs生物合成后,进行了两项实验测定(A和B)。在测定A中,在相互作用15天和30天后评估AgNPs对虫卵的杀卵活性。在测定B中,在相互作用30天后测量虫卵的抑制(发育)情况。测定A的结果表明,到实验结束时,AgNPs平均破坏了47%的受试虫卵,造成了显著的结构损伤。在测定B中,30天结束时观察到抑制率为88%。AgNP的杀卵活性结果很有前景,表明未来对这些具有杀卵特性的生物分子进行研究具有潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e252/11728469/4f543e1fa1ff/pathogens-13-01043-g001.jpg

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