Persistence of in Patients with Bacteremia: Incidence, Clinical and Microbiologic Characters, and Outcomes.

The risk factors and outcomes associated with persistent bacteremia are not well-defined. This retrospective cohort study analyzed 214 cases of bacteremia diagnosed between 2005 and 2022 at two university hospitals, focusing on the clinical and microbiologic characteristics and outcomes of persistent bacteremia. Persistent bacteremia, defined as the detection of for ≥5 days after the initial blood culture, occurred in 25.7% of cases and was significantly associated with mechanical ventilation, polymicrobial infections, and increased 30-day mortality. The early administration of appropriate antibiotics reduced the likelihood of persistence. Isolates from persistent cases demonstrated increased biofilm formation. Molecular typing revealed no specific genotype linked to bacteremia persistence. Resistance to trimethoprim-sulfamethoxazole significantly increased over the study period. Our study offers new insights into the under-explored issue of persistent bacteremia, a condition that constitutes a notable proportion of bloodstream infections and carries high mortality.