Hafez Lamiaa O, Brito-Casillas Yeray, Abdelmageed Noha, Alemán-Cabrera Isabel M, Morad Samy A F, Abdel-Raheem Mahmoud H, Wägner Ana M
Department of Pharmacology, Faculty of Veterinary Medicine, Sohag University, Sohag 82524, Egypt.
Instituto Universitario de Investigaciones Biomédicas y Sanitarias, Universidad de Las Palmas de Gran Canaria, 35016 Las Palmas de Gran Canaria, Spain.
Nutrients. 2024 Dec 11;16(24):4278. doi: 10.3390/nu16244278.
For thousands of years, has been widely used as an herbal medicine to treat some diseases and symptoms, including respiratory, gastrointestinal and urogenital ailments. The present study was adapted to document and assemble existing information about and its evidence-based ethnopharmacological activities, with brief reviews on the description, geographical distribution, ecology, medical uses and phytochemistry. A literature review and information up to 2024 was performed in various scientific databases, including PubMed, Science Direct and Google Scholar. The keywords were "Acacia nilotica", "Botany", "ecology", "Traditional uses", "Phytochemistry", "Polyphenols", "Molecular docking", "Ethnopharmacological activities" and "toxicity", among others. has a wide range of uses, with low toxicity, reported in different countries. It can be infused into oils or tea or incorporated into paste, poultice and biscuits, used as an emollient, antidiarrheal, astringent and as an antidote for bite poisons. Glucose and lipid-lowering, anti-inflammatory, analgesic, antipyretic, antioxidant, antihypertensive, antibacterial, antifungal, antiviral and anthelmintic activities are the most prominent. Over 150 chemical components have been identified from that could be associated with its potential actions. Quercetin, rutin, kaempferol, naringenin, catechin, epicatechin, gallic acid, ellagic acid, lupeol and niloticane are its main active constituents. From the research data, and despite the fact that human clinical trials and detailed methodological studies are scarce, has shown wide-ranging activities, though the most robust evidence is related to the treatment of microbial infections, diarrhea, wound and ulcer healing and for topical application. More pharmacological and toxicological studies are required to further elucidate the mechanisms of action, potential side effects, and optimal dosages for these treatments. Additionally, more clinical trials are needed to validate these traditional uses in human populations and to ensure the safety and efficacy of for these applications. This article offers an overview of therapeutic applications by utilizing traditional uses and recent findings on phytochemical studies, and clinical and pharmacological research.
数千年来，（此处原文缺失具体植物名称）一直被广泛用作草药来治疗一些疾病和症状，包括呼吸道、胃肠道和泌尿生殖系统疾病。本研究旨在记录和收集有关（此处原文缺失具体植物名称）及其循证民族药理学活性的现有信息，并对其描述、地理分布、生态学、医学用途和植物化学进行简要综述。在包括PubMed、ScienceDirect和谷歌学术在内的各种科学数据库中进行了截至2024年的文献综述和信息检索。关键词包括“阿拉伯金合欢”、“植物学”、“生态学”、“传统用途”、“植物化学”、“多酚”、“分子对接”、“民族药理学活性”和“毒性”等。（此处原文缺失具体植物名称）在不同国家有广泛用途，毒性较低。它可以被注入油或茶中，或制成糊剂、药膏和饼干，用作润肤剂、止泻剂、收敛剂和咬伤毒药的解毒剂。降血糖、降血脂、抗炎、镇痛、解热、抗氧化、抗高血压、抗菌、抗真菌、抗病毒和驱虫活性最为突出。已从（此处原文缺失具体植物名称）中鉴定出150多种化学成分，这些成分可能与其潜在作用有关。槲皮素、芦丁、山奈酚、柚皮素、儿茶素、表儿茶素、没食子酸、鞣花酸、羽扇豆醇和尼罗烷是其主要活性成分。从研究数据来看，尽管人体临床试验和详细的方法学研究很少，但（此处原文缺失具体植物名称）已显示出广泛的活性，不过最有力的证据与微生物感染、腹泻、伤口和溃疡愈合的治疗以及局部应用有关。需要更多的药理学和毒理学研究来进一步阐明这些治疗的作用机制、潜在副作用和最佳剂量。此外，还需要更多的临床试验来验证这些传统用途在人群中的有效性，并确保（此处原文缺失具体植物名称）在这些应用中的安全性和有效性。本文通过利用传统用途以及植物化学研究、临床和药理学研究的最新发现，对治疗应用进行了概述。
