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属的生物活性化合物、药理作用和药代动力学。

Bioactive Compounds, Pharmacological Actions, and Pharmacokinetics of Genus .

机构信息

Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour 22511, Egypt.

Department of Biological Sciences, National University of Medical Sciences, Islamabad 46000, Pakistan.

出版信息

Molecules. 2022 Oct 28;27(21):7340. doi: 10.3390/molecules27217340.

Abstract

Plants are a promising source of bioactive compounds that can be used to tackle many emerging diseases both infectious and non-infectious. Among different plants, is a very large genus and exhibits a diverse array of bioactive agents with remarkable pharmacological properties against different diseases. , a herb found all over the world, contains approximately more than 1200 species of the Fabaceae family. In the present review, we have collected detailed information on biochemical as well as pharmacological properties. The data were retrieved using different databases, such as Elsevier, PubMed, Science Direct, Google Scholar, and Scopus, and an extensive literature survey was carried out. Studies have shown that possesses several secondary metabolites, including amines, cyanogenic glycosides, flavonoids, alkaloids, seed oils, cyclitols, fluoroacetate, gums, non-protein amino acids, diterpenes, fatty acids, terpenes, hydrolyzable tannins, and condensed tannins. These compounds exhibit a wide range of pharmaceutical applications such as anti-inflammatory, antioxidant, antidiarrheal, antidiabetic, anticancer, antiviral, liver protective effects, and so on. Thus, the literature shows the tremendous phytochemical impact of the genus in medicine. Overall, we recommend that more research should be conducted on the medicinal value and isolation and purification of the effective therapeutic agents from species for the treatment of various ailments.

摘要

植物是生物活性化合物的有前途的来源,可以用于解决许多新兴的传染病和非传染病。在不同的植物中, 是一个非常大的属,表现出多种多样的具有显著药理学特性的生物活性物质,可用于治疗不同的疾病。 ,一种在世界各地都有发现的草本植物,包含大约 1200 多种豆科植物。在本综述中,我们收集了关于生化和药理学特性的详细信息。这些数据是使用不同的数据库检索的,如 Elsevier、PubMed、Science Direct、Google Scholar 和 Scopus,并进行了广泛的文献调查。研究表明, 具有几种次生代谢产物,包括胺、氰苷、类黄酮、生物碱、籽油、环糖醇、氟乙酸盐、树胶、非蛋白氨基酸、二萜、脂肪酸、萜类、可水解单宁和缩合单宁。这些化合物表现出广泛的药物应用,如抗炎、抗氧化、抗腹泻、抗糖尿病、抗癌、抗病毒、肝脏保护作用等。因此,文献表明该属在医学上具有巨大的植物化学影响力。总的来说,我们建议应该对 属的药用价值以及从 属物种中分离和纯化有效治疗剂进行更多的研究,以治疗各种疾病。

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