维生素K在衰老及年龄相关疾病中的保护作用

The Protective Role of Vitamin K in Aging and Age-Related Diseases.

作者信息

Kaźmierczak-Barańska Julia, Karwowski Bolesław T

机构信息

DNA Damage Laboratory of Food Science Department, Faculty of Pharmacy, Medical University of Lodz, ul. Muszynskiego 1, 90-151 Lodz, Poland.

出版信息

Nutrients. 2024 Dec 16;16(24):4341. doi: 10.3390/nu16244341.

DOI:10.3390/nu16244341

PMID:39770962

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11676630/

Abstract

Aging is an inevitable aspect of life, but age-related diseases are not an inseparable part of the aging process, and their risk can be reduced through a healthy lifestyle. Vitamin K has a broader impact than just blood clotting, and yet it remains overshadowed by other vitamins and underestimated by both doctors and consumers. Vitamin K (VK) is a multifunctional micronutrient with anti-inflammatory and antioxidant properties, whose deficiency may cause age-related diseases such as cardiovascular diseases, neurodegenerative diseases and osteoporosis. There is a growing body of evidence supporting the role of vitamin K as a protective nutrient in aging and inflammation. This review summarizes the current knowledge regarding the molecular aspects of the protective role of vitamin K in aging and age-related diseases and its clinical implications.

摘要

衰老是生命中不可避免的一个方面，但与年龄相关的疾病并非衰老过程中不可分割的一部分，通过健康的生活方式可以降低其风险。维生素K的影响比仅仅在血液凝固方面更为广泛，然而它仍然被其他维生素所掩盖，并且被医生和消费者低估。维生素K（VK）是一种具有抗炎和抗氧化特性的多功能微量营养素，其缺乏可能导致与年龄相关的疾病，如心血管疾病、神经退行性疾病和骨质疏松症。越来越多的证据支持维生素K作为一种在衰老和炎症中起保护作用的营养素的作用。本综述总结了目前关于维生素K在衰老和与年龄相关疾病中的保护作用的分子方面及其临床意义的知识。