骨骼健康。维生素K的新作用？
Bone health. New role for vitamin K?
作者信息
Ryan-Harshman Milly, Aldoori Walid
机构信息
FEAST Enterprises, Oshawa, Ont.
出版信息
Can Fam Physician. 2004 Jul;50:993-7.
OBJECTIVE
To assess growing evidence that vitamin K (phylloquinone) plays an important role in bone health and, subsequently, in prevention of osteoporotic fractures.
QUALITY OF EVIDENCE
We searched MEDLINE from January 1972 to December 2002 using the key words vitamin K and bone health. We reviewed 30 articles that seemed relevant or had a human focus. All evidence can be categorized as level II.
MAIN MESSAGE
Evidence suggests that dietary phylloquinone intake of <100 microg daily might not be optimal for bone health. Low intake of vitamin K could contribute to osteoporosis and subsequent fracture due to the undercarboxylation of osteocalcin.
CONCLUSION
Family physicians need to be aware of the importance of encouraging adequate vitamin K intake, particularly among institutionalized elderly people, to prevent increased bone resorption. Further study is needed to determine the exact role of vitamin K in bone metabolism, and methods of assessing vitamin K requirements need to be standardized.
目的
评估越来越多的证据，即维生素K（叶绿醌）在骨骼健康以及随后预防骨质疏松性骨折中发挥重要作用。
证据质量
我们使用关键词“维生素K”和“骨骼健康”在1972年1月至2002年12月期间检索了MEDLINE数据库。我们审查了30篇似乎相关或以人为研究对象的文章。所有证据均可归类为二级证据。
主要信息
有证据表明，每日膳食中叶绿醌摄入量低于100微克可能对骨骼健康并非最佳。由于骨钙素羧化不足，维生素K摄入量低可能导致骨质疏松症及随后的骨折。
结论
家庭医生需要意识到鼓励充足摄入维生素K的重要性，特别是在机构养老的老年人中，以防止骨吸收增加。需要进一步研究以确定维生素K在骨代谢中的确切作用，并且评估维生素K需求的方法需要标准化。
Zotero 插件